BioMed Research International

BioMed Research International / 2001 / Article

Review article | Open Access

Volume 1 |Article ID 918781 |

Laila Zahed, "The Spectrum of β-Thalassemia Mutations in the Arab Populations", BioMed Research International, vol. 1, Article ID 918781, 4 pages, 2001.

The Spectrum of β-Thalassemia Mutations in the Arab Populations


The Arab countries encompass a wide region stretching from the Persian Gulf to the Atlantic Ocean. The Arab population is quite heterogeneous and has experienced various invasions and migrations throughout history. β-thalassemia is endemic in all countries of the Arab world. Our review of the molecular basis of β-thalassemia in various Arab countries reveals the presence of 52 mutations, which are mostly of Mediterranean and Asian origin. The distribution of mutations reflects the geographical and historical backgrounds of each region. However, no specific mutation is confined to the Arabs, although some Arab countries do have unique mutations.

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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