Review article | Open Access
William L. Rust, Stephen W. Carper, George E. Plopper, "The Promise of Integrins as Effective Targets for Anticancer Agents", BioMed Research International, vol. 2, Article ID 653162, 7 pages, 2002. https://doi.org/10.1155/S1110724302204015
The Promise of Integrins as Effective Targets for Anticancer Agents
This review will briefly describe integrin function, address why integrins are attractive targets for chemotherapeutic drug design, and discuss some ongoing studies aimed at inhibiting integrin activity. Integrins are cell surface heterodimeric receptors. They modulate many cellular processes including: growth, death (apoptosis), adhesion, migration, and invasion by activating several signaling pathways. Many potential chemotherapeutic agents target integrins directly (eg, polypeptides, monoclonal antibodies, adenovirus vectors). These agents may be clinically useful in controlling the metastatic spread of cancer.
Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.