BioMed Research International

BioMed Research International / 2003 / Article
Special Issue

Gene Therapy — Part I

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Review article | Open Access

Volume 2003 |Article ID 375914 | https://doi.org/10.1155/S1110724303209013

Takao Kanzawa, Hideaki Ito, Yasuko Kondo, Seiji Kondo, "Current and Future Gene Therapy for Malignant Gliomas", BioMed Research International, vol. 2003, Article ID 375914, 10 pages, 2003. https://doi.org/10.1155/S1110724303209013

Current and Future Gene Therapy for Malignant Gliomas

Received04 Jun 2002
Accepted19 Jul 2002

Abstract

Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative treatment. Many gene therapeutic approaches have demonstrated efficacy in experimental animal models. However, the current clinical trials are disappointing. This review focuses on current therapeutic genes/vectors/delivery systems/targeting strategies in order to introduce updated trends and hopefully indicate prospective gene therapy for malignant gliomas.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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