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Journal of Biomedicine and Biotechnology
Volume 2003 (2003), Issue 2, Pages 102-109
Review article

Targeting Radiotherapy to Cancer by Gene Transfer

Targeted Therapy Group, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, Scotland

Received 7 July 2002; Accepted 19 July 2002

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Targeted radionuclide therapy is an alternative method of radiation treatment which uses a tumor-seeking agent carrying a radioactive atom to deposits of tumor, wherever in the body they may be located. Recent experimental data signifies promise for the amalgamation of gene transfer with radionuclide targeting. This review encompasses aspects of the integration of gene manipulation and targeted radiotherapy, highlighting the possibilities of gene transfer to assist the targeting of cancer with low molecular weight radiopharmaceuticals.