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Journal of Biomedicine and Biotechnology
Volume 2003 (2003), Issue 2, Pages 138-148
Review article

Gene Therapy for Cardiovascular Disease

BHF Blood Pressure Group, Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow G11 6NT, Scotland

Received 5 June 2002; Accepted 19 July 2002

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic. Perhaps the overwhelming drive for the increase in vascular gene transfer studies is the current lack of successful long-term pharmacological treatments for complex cardiovascular diseases. The increase in cardiovascular disease to epidemic proportions has also led many to conclude that drug therapy may have reached a plateau in its efficacy and that gene therapy may represent a realistic solution to a long-term problem. Here, we discuss gene delivery approaches and target diseases.