BioMed Research International

BioMed Research International / 2003 / Article
Special Issue

Proteomics in Health and Disease Part I

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Review article | Open Access

Volume 2003 |Article ID 705194 |

Halima Bensmail, Abdelali Haoudi, "Postgenomics: Proteomics and Bioinformatics in Cancer Research", BioMed Research International, vol. 2003, Article ID 705194, 14 pages, 2003.

Postgenomics: Proteomics and Bioinformatics in Cancer Research

Received26 Sep 2002
Revised30 Nov 2002
Accepted30 Nov 2002


Now that the human genome is completed, the characterization of the proteins encoded by the sequence remains a challenging task. The study of the complete protein complement of the genome, the “proteome,” referred to as proteomics, will be essential if new therapeutic drugs and new disease biomarkers for early diagnosis are to be developed. Research efforts are already underway to develop the technology necessary to compare the specific protein profiles of diseased versus nondiseased states. These technologies provide a wealth of information and rapidly generate large quantities of data. Processing the large amounts of data will lead to useful predictive mathematical descriptions of biological systems which will permit rapid identification of novel therapeutic targets and identification of metabolic disorders. Here, we present an overview of the current status and future research approaches in defining the cancer cell's proteome in combination with different bioinformatics and computational biology tools toward a better understanding of health and disease.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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