BioMed Research International

BioMed Research International / 2003 / Article
Special Issue

Gene Therapy — Part II

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Review article | Open Access

Volume 2003 |Article ID 740305 |

Tracy Robson, David G. Hirst, "Transcriptional Targeting in Cancer Gene Therapy", BioMed Research International, vol. 2003, Article ID 740305, 28 pages, 2003.

Transcriptional Targeting in Cancer Gene Therapy

Received10 Jun 2002
Accepted19 Jul 2002


Cancer gene therapy has been one of the most exciting areas of therapeutic research in the past decade. In this review, we discuss strategies to restrict transcription of transgenes to tumour cells. A range of promoters which are tissue-specific, tumour-specific, or inducible by exogenous agents are presented. Transcriptional targeting should prevent normal tissue toxicities associated with other cancer treatments, such as radiation and chemotherapy. In addition, the specificity of these strategies should provide improved targeting of metastatic tumours following systemic gene delivery. Rapid progress in the ability to specifically control transgenes will allow systemic gene delivery for cancer therapy to become a real possibility in the near future.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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