BioMed Research International

BioMed Research International / 2004 / Article

Research article | Open Access

Volume 2004 |Article ID 627386 |

Amr Amin, "Genetic Cross-Talk During Head Development in Drosophila", BioMed Research International, vol. 2004, Article ID 627386, 8 pages, 2004.

Genetic Cross-Talk During Head Development in Drosophila

Received22 Feb 2003
Accepted03 Jun 2003


The dorsal head vertex of Drosophila is specified mainly by the orthodenticle (otd) gene. The expression and the function of otd are regulated by the concerted action of many genes including hedgehog (hh) and notch (N). These genes are components of a meshwork of signaling transduction pathways that interact to form the dorsal head capsule of the fruit fly. Loss-of-function Hh mutants lack ocelli; however, loss-of-function N mutants lack a different domain of the dorsal head vertex. This report provides new evidence that the Hh and N pathways are two epistatic signaling cascades that act genetically upstream of the dorsal head capsule specification gene.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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