BioMed Research International

BioMed Research International / 2004 / Article
Special Issue

Anthocyanins—More Than Nature's Colour

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Review article | Open Access

Volume 2004 |Article ID 815182 | https://doi.org/10.1155/S1110724304403040

De-Xing Hou, Makoto Fujii, Norihiko Terahara, Makoto Yoshimoto, "Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins", BioMed Research International, vol. 2004, Article ID 815182, 5 pages, 2004. https://doi.org/10.1155/S1110724304403040

Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins

Received03 Mar 2004
Revised19 May 2004
Accepted14 Jun 2004

Abstract

Anthocyanins are polyphenolic ring-based flavonoids, and are widespread in fruits and vegetables of red-blue color. Epidemiological investigations and animal experiments have indicated that anthocyanins may contribute to cancer chemoprevention. The studies on the mechanism have been done recently at molecular level. This review summarizes current molecular bases for anthocyanidins on several key steps involved in cancer chemoprevention: (i) inhibition of anthocyanidins in cell transformation through targeting mitogen-activated protein kinase (MAPK) pathway and activator protein 1 (AP-1) factor; (ii) suppression of anthocyanidins in inflammation and carcinogenesis through targeting nuclear factor kappa B (NF-κB) pathway and cyclooxygenase 2 (COX-2) gene; (iii) apoptotic induction of cancer cells by anthocyanidins through reactive oxygen species (ROS) / c-Jun NH2-terminal kinase (JNK)-mediated caspase activation. These data provide a first molecular view of anthocyanidins contributing to cancer chemoprevention.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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