BioMed Research International

BioMed Research International / 2005 / Article
Special Issue

Data Mining in Genomics and Proteomics

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Research article | Open Access

Volume 2005 |Article ID 213654 |

Michał Brylinski, Leszek Konieczny, Patryk Czerwonko, Wiktor Jurkowski, Irena Roterman, "Early-Stage Folding in Proteins (In Silico) Sequence-to-Structure Relation", BioMed Research International, vol. 2005, Article ID 213654, 15 pages, 2005.

Early-Stage Folding in Proteins (In Silico) Sequence-to-Structure Relation

Received16 Sep 2004
Revised03 Jan 2005
Accepted05 Jan 2005


A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were introduced for structure classification. The early-stage folding conformations were used as the objects for structure analysis and classification. The degree of determinability was estimated for the sequence-to-structure and structure-to-sequence relations. Probability calculus and informational entropy were applied for quantitative estimation of the mutual relation between them. The structural motifs representing different forms of loops and bends were found to favor particular sequences in structure-to-sequence analysis.

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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