BioMed Research International

BioMed Research International / 2005 / Article

Research article | Open Access

Volume 2005 |Article ID 328927 | https://doi.org/10.1155/JBB.2005.287

Paulus Tsui, Marvin Rubenstein, Patrick Guinan, "Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis", BioMed Research International, vol. 2005, Article ID 328927, 4 pages, 2005. https://doi.org/10.1155/JBB.2005.287

Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis

Received26 May 2004
Revised27 Jul 2004
Accepted09 Oct 2004

Abstract

Our aim is the identification and correlation of changes in tumor-associated protein expression which results from therapy. LNCaP tumors, excised from nude mice treated either by orchiectomy or with the chemotherapeutic agent paclitaxel, were evaluated for the expression of proteins and receptors associated with growth, differentiation, and angiogenesis using immunohistologic procedures. Compared to untreated control tumors, both treatments reduced the expression of vascular endothelial growth factor (VEGF), prostate-specific membrane antigen (PSMA), prostate-specific antigen (PSA), androgen receptor (AR), and epidermal growth factor receptor (EGFR). The effect of paclitaxel treatment on AR expression was the most significant (P=.005). Of particular interest was identifying a significant correlation (P<.000801) between PSMA and VEGF expression regardless of treatment modality. These altered expressions suggest that PSMA may also be a marker for angiogenesis and could represent a target for deliverable agents recognizing either prostatic tumors or endothelial development. Cell surface PSMA would then present a unique target for treatment of patients early in their development of prostatic metastases.

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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