Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2006, Article ID 13474, 10 pages
http://dx.doi.org/10.1155/JBB/2006/13474
Review Article

Histone Deacetylase Enzymes as Potential Drug Targets in Cancer and Parasitic Diseases

1Service de Chirurgie Digestive et Générale, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, Marseille 13009, France
2IRD UR008 “Pathogénie des Trypanosomatidés”, Centre IRD de Montpellier, Institut de la Recherche pour le Développement, 911 Avenue Agropolis, BP 64501, Montpellier Cedex 5 34394, France

Received 29 December 2005; Revised 19 March 2006; Accepted 22 March 2006

Copyright © 2006 Mehdi Ouaissi and Ali Ouaissi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [41 citations]

The following is the list of published articles that have cited the current article.

  • Christian Hildmann, Daniel Riester, and Andreas Schwienhorst, “Histone deacetylases - An important class of cellular regulators with a variety of functions,” Applied Microbiology and Biotechnology, vol. 75, no. 3, pp. 487–497, 2007. View at Publisher · View at Google Scholar
  • Daniel Riester, Christian Hildmann, and Andreas Schwienhorst, “Histone deacetylase inhibitors - Turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases,” Applied Microbiology and Biotechnology, vol. 75, no. 3, pp. 499–514, 2007. View at Publisher · View at Google Scholar
  • Christophe Le Tourneau, Sandrine Faivre, and Lillian L. Siu, “Molecular targeted therapy of head and neck cancer: Review and clinical development challenges,” European Journal of Cancer, vol. 43, no. 17, pp. 2457–2466, 2007. View at Publisher · View at Google Scholar
  • K. L. Rice, I. Hormaeche, and J. D. Licht, “Epigenetic regulation of normal and malignant hematopoiesis,” Oncogene, vol. 26, no. 47, pp. 6697–6714, 2007. View at Publisher · View at Google Scholar
  • Konstantin V. Balakin, Alex S. Kiselyov, Yan A. Ivanenkov, and Sergey E. Tkachenko, “Histone deacetylase inhibitors in cancer therapy: Latest developments, trends and medicinal chemistry perspective,” Anti-Cancer Agents in Medicinal Chemistry, vol. 7, no. 5, pp. 576–592, 2007. View at Publisher · View at Google Scholar
  • Hsin-Yi Wu, Fu-Yung Huang, Yu-Chen Chang, Meng-Chun Hsieh, and Pao-Chi Liao, “Strategy for determination of in vitro protein acetylation sites by using isotope-labeled acetyl coenzyme a and liquid chromatography-mass Spectrometry,” Analytical Chemistry, vol. 80, no. 16, pp. 6178–6189, 2008. View at Publisher · View at Google Scholar
  • Paula A. Abreu, Gisela Dellamora-Orriz, Luiz R. Leao-Ferreira, Maria Gouveia, Esteban Braggio, Ilana Zalcberg, Dilvani O. Santos, Saulo Bourguinhon, Lucio M. Cabral, Carlos R. Rodrigues, and Helena C. Castro, “DNA methylation: A promising target for the twenty-first century,” Expert Opinion on Therapeutic Targets, vol. 12, no. 8, pp. 1035–1047, 2008. View at Publisher · View at Google Scholar
  • Paula A. Abreu, Gisela Dellamora-Ortiz, Luiz R. Leão-Ferreira, Maria Gouveia, Esteban Braggio, Ilana Zalcberg, Dilvani O. Santos, Saulo Bourguinhon, Lucio M. Cabral, Carlos R. Rodrigues, and Helena C. Castro, “DNA methylation: A promising target for the twenty-first century,” Expert Opinion on Therapeutic Targets, vol. 12, no. 8, pp. 1035–1047, 2008. View at Publisher · View at Google Scholar
  • Patricia Respuela, Marcela Ferella, Alvaro Rada-Iglesias, and Lena Aslund, “Histone acetylation and methylation at sites initiating divergent polycistronic transcription in Trypanosoma cruzi,” Journal Of Biological Chemistry, vol. 283, no. 23, pp. 15884–15892, 2008. View at Publisher · View at Google Scholar
  • Mehdi Ouaïssi, Igor Sielezneff, Ricardo Silvestre, Bernard Sastre, Jean-Paul Bernard, Joelle Simony Lafontaine, Marie José Payan, Laetitia Dahan, Nicolas Pirrò, Jean François Seitz, Eric Mas, Dominique Lombardo, and Ali Ouaissi, “High Histone Deacetylase 7 (HDAC7) Expression Is Significantly Associated with Adenocarcinomas of the Pancreas,” Annals of Surgical Oncology, vol. 15, no. 8, pp. 2318–2328, 2008. View at Publisher · View at Google Scholar
  • M. Ouaissi, S. Cabral, J. Tavares, A. Cordeiro da Silva, F. Mathieu-Daude, E. Mas, J. P. Bernard, B. Sastre, D. Lombardo, and Ali Ouaissi, “Histone deacetylase (HDAC) encoding gene expression in pancreatic cancer cell lines and cell sensitivity to HDAC inhibitors,” Cancer Biology & Therapy, vol. 7, no. 4, pp. 523–531, 2008. View at Publisher · View at Google Scholar
  • Laura Lafon-Hughes, Maria Vittoria Di Tomaso, Leticia Mendez-Acuna, and Wilner Martinez-Lopez, “Chromatin-remodelling mechanisms in cancer,” Mutation Research-Reviews in Mutation Research, vol. 658, no. 3, pp. 191–214, 2008. View at Publisher · View at Google Scholar
  • Frédérik Oger, Florence Dubois, Stéphanie Caby, Christophe Noël, Jocelyne Cornette, Benjamin Bertin, Monique Capron, and Raymond J. Pierce, “The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni,” Biochemical and Biophysical Research Communications, vol. 377, no. 4, pp. 1079–1084, 2008. View at Publisher · View at Google Scholar
  • Jie Chen, Changsheng Du, Jiuhong Kang, and Jianmin Wang, “Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis,” Chemico-Biological Interactions, vol. 171, no. 1, pp. 26–36, 2008. View at Publisher · View at Google Scholar
  • Matthias Körner, and Ulrich Tibes, “5 Histone Deacetylase Inhibitors: A Novel Class of Anti-Cancer Agents on its Way to the Market,” Progress in Medicinal Chemistry Volume 46, vol. 46, pp. 205–280, 2008. View at Publisher · View at Google Scholar
  • Nina Saban, and Maro Bujak, “Hydroxyurea and hydroxamic acid derivatives as antitumor drugs,” Cancer Chemotherapy and Pharmacology, vol. 64, no. 2, pp. 213–221, 2009. View at Publisher · View at Google Scholar
  • Sundar Jagannath, Meletios A. Dimopoulos, and Sagar Lonial, “Combined proteasome and histone deacetylase inhibition: A promising synergy for patients with relapsed/refractory multiple myeloma,” Leukemia Research, vol. 34, no. 9, pp. 1111–1118, 2010. View at Publisher · View at Google Scholar
  • William Guerrant, Sandra C. Mwakwari, Po C. Chen, Shabana I. Khan, Babu L. Tekwani, and Adegboyega K. Oyelere, “A Structure-Activity Relationship Study of the Antimalarial and Antileishmanial Activities of Nonpeptide Macrocyclic Histone Deacetylase Inhibitors,” Chemmedchem, vol. 5, no. 8, pp. 1232–1235, 2010. View at Publisher · View at Google Scholar
  • Florian Thaler, Mario Varasi, Andrea Colombo, Roberto Boggio, Davide Munari, Nickolas Regalia, Marco G. Rozio, Veronica Reali, Anna E. Resconi, Antonello Mai, Stefania Gagliardi, Giulio Dondio, Saverio Minucci, and Ciro Mercurio, “Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors,” Chemmedchem, vol. 5, no. 8, pp. 1359–1372, 2010. View at Publisher · View at Google Scholar
  • S. Schmalbach, and S. Petri, “Histone Deacetylation and Motor Neuron Degeneration,” Cns & Neurological Disorders-Drug Targets, vol. 9, no. 3, pp. 279–284, 2010. View at Publisher · View at Google Scholar
  • Claas Janssen, Sonja Schmalbach, Sebastian Boeselt, Alexander Sarlette, Reinhard Dengler, and Susanne Petri, “Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis,” Journal Of Neuropathology And Experimental Neurology, vol. 69, no. 6, pp. 573–581, 2010. View at Publisher · View at Google Scholar
  • Kenneth B. Hymes, “The Role of Histone Deacetylase Inhibitors in the Treatment of Patients With Cutaneous T-Cell Lymphoma,” Clinical Lymphoma Myeloma and Leukemia, vol. 10, no. 2, pp. 98–109, 2010. View at Publisher · View at Google Scholar
  • Rong He, Yufeng Chen, Yihua Chen, Andrei V. Ougolkov, Jin-San Zhang, Doris N. Savoy, Daniel D. Billadeau, and Alan P. Kozikowski, “Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as Anticancer Agents,” Journal Of Medicinal Chemistry, vol. 53, no. 3, pp. 1347–1356, 2010. View at Publisher · View at Google Scholar
  • Vishal Patil, William Guerrant, Po C. Chen, Berkley Gryder, Derek B. Benicewicz, Shabana I. Khan, Babu L. Tekwani, and Adegboyega K. Oyelere, “Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group,” Bioorganic & Medicinal Chemistry, vol. 18, no. 1, pp. 415–425, 2010. View at Publisher · View at Google Scholar
  • Jomar Patricio Monteiro, and Maria Isabel Nogueira Cano, “SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: An overview,” Protein and Peptide Letters, vol. 18, no. 2, pp. 167–173, 2011. View at Publisher · View at Google Scholar
  • Saroj Kunnakkat, Maya Mathew, and Ashwatha Narayana, “Antiangiogenic therapy in the management of brain tumors: a clinical overview,” Cancer Chemotherapy and Pharmacology, vol. 70, no. 3, pp. 353–363, 2012. View at Publisher · View at Google Scholar
  • Ouaïssi Mehdi, Mas Eric, Ouaïssi Ali, Silvy Françoise, Costa Lima Sofia, Giger Urs, Zemmour Kevin, Sastre Bernard, Sielezneff Igor, Cordeiro-Da-Silva Anabela, and Lombardo Dominique, “HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA),” Pancreatology, vol. 12, no. 2, pp. 146–155, 2012. View at Publisher · View at Google Scholar
  • Manish K. Gupta, Gagandip Singh, and Swati Guptapp. 173–204, 2013. View at Publisher · View at Google Scholar
  • Florian Thaler, and Ciro Mercurio, “Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next,” ChemMedChem, 2013. View at Publisher · View at Google Scholar
  • Kumar Saurav, Wenjun Zhang, Subhasish Saha, Haibo Zhang, Sumei Li, Qingbo Zhang, Zhengchao Wu, Guangtao Zhang, Yiguang Zhu, and Gaurav Verma, “In silico Molecular Docking, Preclinical Evaluation of Spiroindimicins A-D, lynamicin A and D isolated from deep marine sea derived Streptomyces sp SCSIO 03032,” Interdisciplinary Sciences-Computational Life Sciences, vol. 6, no. 3, pp. 187–196, 2014. View at Publisher · View at Google Scholar
  • Srinivasaraghavan Kannan, Jelena Melesina, Alexander Hauser, Alokta Chakrabarti, tino Heimburg, Karin Schmidtkunz, Alexandra Walter, Martin Marek, Raymond J Pierce, Christophe Romier, Manfred Jung, and Wolfgang Sippl, “Discovery of Inhibitors of Schistosoma Mansoni HDAC8 by Combining Homology Modeling, Virtual Screening and In Vitro Validation,” Journal of Chemical Information and Modeling, pp. 140922105136002, 2014. View at Publisher · View at Google Scholar
  • Vaishali Patil, and Satya Gupta, “Oncolytic Viruses and Histone Deacetylase Inhibitors,” Cancer-Causing Viruses and Their Inhibitors, pp. 437–466, 2014. View at Publisher · View at Google Scholar
  • Mehdi Ouaïssi, Olivier Turrini, Catherine Hubert, Guillaume Louis, Jean-François Gigot, and Jean-Yves Mabrut, “Vascular resection during radical resection of pancreatic adenocarcinomas: evolution over the past 15 years,” Journal of Hepato-Biliary-Pancreatic Sciences, 2014. View at Publisher · View at Google Scholar
  • Bidyut Purkait, Ayan K. Ghosh, Pradeep Das, Ruby Singh, Kirti Wasnik, Sushmita Das, Ashish Kumar, Mark Paine, Manas Dikhit, Dharmendra Singh, and Abul H. Sardar, “Up-regulation of silent information regulator 2 (Sir2) is associated with amphotericin B resistance in clinical isolates of Leishmania donovani,” Journal of Antimicrobial Chemotherapy, vol. 70, no. 5, pp. 1343–1356, 2014. View at Publisher · View at Google Scholar
  • Rajendra K. Baharia, Rati Tandon, Tanuj Sharma, Manish K. Suthar, Sanchita Das, Mohammad Imran Siddiqi, Jitendra Kumar Saxena, Shyam Sunder, and Anuradha Dube, “Recombinant NAD-dependent SIR-2 Protein of Leishmania donovani: Immunobiochemical Characterization as a Potential Vaccine against Visceral Leishmanias,” Plos Neglected Tropical Diseases, vol. 9, no. 3, 2015. View at Publisher · View at Google Scholar
  • Angela K. Carrillo, W. Armand Guiguemde, and R. Kiplin Guy, “Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT),” Bioorganic & Medicinal Chemistry, 2015. View at Publisher · View at Google Scholar
  • Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Martin Marek, Jelena Melesina, Alexander-Thomas Hauser, Tajith B. Shaik, Sylvie Duclaud, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Raymond J. Pierce, Manfred Jung, and Wolfgang Sippl, “ Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis ,” Journal of Medicinal Chemistry, 2016. View at Publisher · View at Google Scholar
  • Iván Cheng-Sánchez, Cristina García-Ruiz, Guillermo A. Guerrero-Vásquez, and Francisco Sarabia, “An Olefin Cross-Metathesis Approach to Depudecin and Stereoisomeric Analogues,” The Journal of Organic Chemistry, 2017. View at Publisher · View at Google Scholar
  • Martin Marek, Tajith B. Shaik, Manfred Jung, Wolfgang Sippl, Raymond J. Pierce, and Christophe Romier, “ Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni ,” Biologie Aujourd'hui, vol. 210, no. 4, pp. 311–320, 2017. View at Publisher · View at Google Scholar
  • Shawgi Hago Almugadam, Alessandro Trentini, Martina Maritati, Carlo Contini, Gianluca Rugna, Tiziana Bellini, Maria Cristina Manfrinato, Franco Dallocchio, and Stefania Hanau, “Influence of 6-aminonicotinamide (6AN) on Leishmania promastigotes evaluated by metabolomics: Beyond the pentose phosphate pathway,” Chemico-Biological Interactions, 2018. View at Publisher · View at Google Scholar
  • Rangeline Azevedo da Silva, Leandro de Mattos Pereira, Melise Chaves Silveira, Rodrigo Jardim, and Antonio Basilio de Miranda, “Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum,” Plos One, vol. 13, no. 5, pp. e0197511, 2018. View at Publisher · View at Google Scholar