The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity 
      and Activates the Intrarenal Renin-Angiotensin System

Kim, Suyeon; Soltani-Bejnood, Morvarid; Quignard-Boulange, Annie; Massiera, Florence; Teboul, Michele; Ailhaud, Gerard; Kim, Jung Han; Moustaid-Moussa, Naima; Voy, Brynn H.

doi:https://doi.org/10.1155/JBB/2006/27012

BioMed Research International

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Volume 2006 | Article ID 027012 | https://doi.org/10.1155/JBB/2006/27012

The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System

Suyeon Kim,¹Morvarid Soltani-Bejnood,¹Annie Quignard-Boulange,³Florence Massiera,⁴Michele Teboul,⁴Gerard Ailhaud,⁴Jung Han Kim,¹Naima Moustaid-Moussa,¹and Brynn H. Voy²

Received06 Apr 2006

Revised17 Jul 2006

Accepted18 Jul 2006

Published02 Aug 2006

Abstract

Background. The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results. A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice. Conclusion. These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.

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Copyright © 2006 Suyeon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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