Reduced Atherosclerotic Lesion Size in <mml:math id="E1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>P</mml:mi></mml:math>-Selectin Deficient Apolipoprotein <mml:math id="E2" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>E</mml:mi></mml:math>-Knockout Mice Fed a Chow but Not a Fat Diet

Bourdillon, Marie-Claude; Randon, Jacques; Barek, Lydie; Zibara, Kazem; Covacho, Chantal; Poston, Robin N; Chignier, Elza; McGregor, John L.

doi:https://doi.org/10.1155/JBB/2006/49193

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Research Article | Open Access

Volume 2006 | Article ID 049193 | https://doi.org/10.1155/JBB/2006/49193

Reduced Atherosclerotic Lesion Size in P-Selectin Deficient Apolipoprotein E-Knockout Mice Fed a Chow but Not a Fat Diet

Marie-Claude Bourdillon,¹Jacques Randon,¹Lydie Barek,¹Kazem Zibara,¹Chantal Covacho,¹Robin N Poston,²Elza Chignier,¹and John L. McGregor^3,4

Received15 Sept 2005

Revised27 Dec 2005

Accepted29 Dec 2005

Published04 Apr 2006

Abstract

Endothelial cells lining atherosclerotic, but not healthy sites, on human arteries express P-selectin. We investigated the role of P-selectin on the development of vascular lesions in an ApoE−/− male mice. Double-knockout (ApoE−/−, P-selectin-/-; DKO) were compared to single-knockout (ApoE−/−; SKO) mice. They were fed a chow or fat diet for 3, 6, 15, and 20 weeks, without any differences in cholesterol levels. DKO mice fed a chow diet exhibited a ratio of lesion area over media lower than SKO mice, for 3 (P<.03) , 6 (P<.001), and 15 (P<.02) weeks. DKO mice fed a fat diet showed a lower ratio only at 3 weeks. P-selectin deficiency in ApoE−/− mice has a protective effect in atherosclerotic lesions development. Reduction of lesion size depends on diet type and duration. A fat diet could neutralize the beneficial effects of P-selectin deficiency, inducing atherosclerotic lesions via probably other adhesion molecules.

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Copyright © 2006 Marie-Claude Bourdillon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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