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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 49193, 8 pages
http://dx.doi.org/10.1155/JBB/2006/49193
Research Article

Reduced Atherosclerotic Lesion Size in P-Selectin Deficient Apolipoprotein E-Knockout Mice Fed a Chow but Not a Fat Diet

1EA-3740, INSERM-IFR62, Faculté de Médecine Laënnec, Université Claude Bernard Lyon 1, 7 rue Guillaume Paradin, Lyon 69372, France
2Centre for Cardiovascular Biology and Medicine, Guy's Campus, King's College London, London SE1 1UL, United Kingdom
3INSERM Unit 689, Hospital Lariboisière, Paris, France
4Genomics and Atherothrombosis Laboratory, Thrombosis Research Institute, London SW3 6LR, United Kingdom

Received 15 September 2005; Revised 27 December 2005; Accepted 29 December 2005

Copyright © 2006 Marie-Claude Bourdillon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G I Johnston, R G Cook, and R P McEver, “Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation,” Cell, vol. 56, no. 6, pp. 1033–1044, 1989. View at Publisher · View at Google Scholar
  2. T A Springer, “Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm,” Cell, vol. 76, no. 2, pp. 301–314, 1994. View at Publisher · View at Google Scholar
  3. T N Mayadas, R C Johnson, H Rayburn, R O Hynes, and D D Wagner, “Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice,” Cell, vol. 74, no. 3, pp. 541–554, 1993. View at Publisher · View at Google Scholar
  4. M Subramaniam, S Saffaripour, L Van De Water et al., “Role of endothelial selectins in wound repair,” The American Journal of Pathology, vol. 150, no. 5, pp. 1701–1709, 1997. View at Google Scholar
  5. R R Johnson-Tidey, J L McGregor, P R Taylor, and R N Poston, “Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1,” The American Journal of Pathology, vol. 144, no. 5, pp. 952–961, 1994. View at Google Scholar
  6. M F Nageh, E T Sandberg, K R Marotti et al., “Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 8, pp. 1517–1520, 1997. View at Google Scholar
  7. A Kumar, J L Hoover, C A Simmons, V Lindner, and R J Shebuski, “Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice,” Circulation, vol. 96, no. 12, pp. 4333–4342, 1997. View at Google Scholar
  8. S Hayashi, N Watanabe, K Nakazawa et al., “Roles of P-selectin in inflammation, neointimal formation, and vascular remodeling in balloon-injured rat carotid arteries,” Circulation, vol. 102, no. 14, pp. 1710–1717, 2000. View at Google Scholar
  9. R L Reddick, S H Zhang, and N Maeda, “Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression,” Arteriosclerosis and Thrombosis, vol. 14, no. 1, pp. 141–147, 1994. View at Google Scholar
  10. J A Piedrahita, S H Zhang, J R Hagaman, P M Oliver, and N Maeda, “Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 10, pp. 4471–4475, 1992. View at Publisher · View at Google Scholar
  11. S Ishibashi, M S Brown, J L Goldstein, R D Gerard, R E Hammer, and J Herz, “Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery,” The Journal of Clinical Investigation, vol. 92, no. 2, pp. 883–893, 1993. View at Google Scholar
  12. Y Nakashima, A S Plump, E W Raines, J L Breslow, and R Ross, “ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree,” Arteriosclerosis and Thrombosis, vol. 14, no. 1, pp. 133–140, 1994. View at Google Scholar
  13. S Ishibashi, J L Goldstein, M S Brown, J Herz, and D K Burns, “Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice,” The Journal of Clinical Investigation, vol. 93, no. 5, pp. 1885–1893, 1994. View at Google Scholar
  14. S E Roselaar, P X Kakkanathu, and A Daugherty, “Lymphocyte populations in atherosclerotic lesions of and LDL ApoE/ and LDL receptor/ mice. Decreasing density with disease progression,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 8, pp. 1013–1018, 1996. View at Google Scholar
  15. J W Knowles and N Maeda, “Genetic modifiers of atherosclerosis in mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 11, pp. 2336–2345, 2000. View at Google Scholar
  16. R C Johnson, S M Chapman, Z M Dong et al., “Absence of P-selectin delays fatty streak formation in mice,” The Journal of Clinical Investigation, vol. 99, no. 5, pp. 1037–1043, 1997. View at Google Scholar
  17. Z M Dong, S M Chapman, A A Brown, P S Frenette, R O Hynes, and D D Wagner, “The combined role of P- and E-selectins in atherosclerosis,” The Journal of Clinical Investigation, vol. 102, no. 1, pp. 145–152, 1998. View at Google Scholar
  18. Z M Dong, A A Brown, and D D Wagner, “Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice,” Circulation, vol. 101, no. 19, pp. 2290–2295, 2000. View at Google Scholar
  19. R G Collins, R Velji, N V Guevara, M J Hicks, L Chan, and A L Beaudet, “P-selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice,” The Journal of Experimental Medicine, vol. 191, no. 1, pp. 189–194, 2000. View at Publisher · View at Google Scholar
  20. D C Bullard, L Qin, I Lorenzo et al., “P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli,” The Journal of Clinical Investigation, vol. 95, no. 4, pp. 1782–1788, 1995. View at Google Scholar
  21. S H Zhang, R L Reddick, J A Piedrahita, and N Maeda, “Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E,” Science, vol. 258, no. 5081, pp. 468–471, 1992. View at Publisher · View at Google Scholar
  22. P Soriano, C Montgomery, R Geske, and A Bradley, “Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice,” Cell, vol. 64, no. 4, pp. 693–702, 1991. View at Publisher · View at Google Scholar
  23. S V Onrust, P M Hartl, SD Rosen, and D Hanahan, “Modulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic mice,” The Journal of Clinical Investigation, vol. 97, no. 1, pp. 54–64, 1996. View at Google Scholar
  24. S M Hsu, L Raine, and H Fanger, “The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics,” American Journal of Clinical Pathology, vol. 75, no. 6, pp. 816–821, 1981. View at Google Scholar
  25. T C Dawson, W A Kuziel, T A Osahar, and N Maeda, “Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice,” Atherosclerosis, vol. 143, no. 1, pp. 205–211, 1999. View at Publisher · View at Google Scholar
  26. R Ross, “Atherosclerosis—an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Publisher · View at Google Scholar
  27. A Shor, J I Phillips, G Ong, B J Thomas, and D Taylor-Robinson, “Chlamydia pneumoniae in atheroma: consideration of criteria for causality,” Journal of Clinical Pathology, vol. 51, no. 11, pp. 812–817, 1998. View at Google Scholar
  28. K D O'Brien, T O McDonald, A Chait, M D Allen, and C E Alpers, “Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content,” Circulation, vol. 93, no. 4, pp. 672–682, 1996. View at Google Scholar
  29. R N Poston and R R Johnson-Tidey, “Localized adhesion of monocytes to human atherosclerotic plaques demonstrated in vitro: implications for atherogenesis,” The American Journal of Pathology, vol. 149, no. 1, pp. 73–80, 1996. View at Google Scholar
  30. K Iiyama, L Hajra, M Iiyama et al., “Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation,” Circulation Research, vol. 85, no. 2, pp. 199–207, 1999. View at Google Scholar
  31. E Larsen, A Celi, G E Gilbert et al., “PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes,” Cell, vol. 59, no. 2, pp. 305–312, 1989. View at Publisher · View at Google Scholar
  32. S A Hamburger and R P McEver, “GMP-140 mediates adhesion of stimulated platelets to neutrophils,” Blood, vol. 75, no. 3, pp. 550–554, 1990. View at Google Scholar
  33. L A Lasky, “Selectins: interpreters of cell-specific carbohydrate information during inflammation,” Science, vol. 258, no. 5084, pp. 964–969, 1992. View at Publisher · View at Google Scholar
  34. J F Murphy and J L McGregor, “A peptide (P2) derived from the variable heavy chain of an anti-P-selectin monoclonal antibody (LYP20) inhibits leucocyte adhesion to thrombin-activated platelets and endothelial cells,” British Journal of Haematology, vol. 120, no. 4, pp. 605–610, 2003. View at Publisher · View at Google Scholar
  35. K L Moore, N L Stults, S Diaz et al., “Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells,” The Journal of Cell Biology, vol. 118, no. 2, pp. 445–456, 1992. View at Publisher · View at Google Scholar
  36. P S Frenette and D D Wagner, “Insights into selectin function from knockout mice,” Thrombosis and Haemostasis, vol. 78, no. 1, pp. 60–64, 1997. View at Google Scholar
  37. M-C Bourdillon, R N Poston, C Covacho, E Chignier, G Bricca, and J L McGregor, “ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE//ICAM-1/) fed a fat or a chow diet,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 12, pp. 2630–2635, 2000. View at Google Scholar
  38. D Manka, R G Collins, K Ley, A L Beaudet, and I J Sarembock, “Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice,” Circulation, vol. 103, no. 7, pp. 1000–1005, 2001. View at Google Scholar
  39. D Manka, S B Forlow, J M Sanders et al., “Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 6, pp. 1124–1129, 2004. View at Publisher · View at Google Scholar
  40. J W Phillips, K G Barringhaus, J M Sanders et al., “Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice,” Circulation, vol. 107, no. 17, pp. 2244–2249, 2003. View at Publisher · View at Google Scholar
  41. T J Molenaar, J Twisk, S A de Haas et al., “P-selectin as a candidate target in atherosclerosis,” Biochemical Pharmacology, vol. 66, no. 5, pp. 859–866, 2003. View at Publisher · View at Google Scholar
  42. P C Burger and D D Wagner, “Platelet P-selectin facilitates atherosclerotic lesion development,” Blood, vol. 101, no. 7, pp. 2661–2666, 2003. View at Publisher · View at Google Scholar
  43. B C Lutters, M A Leeuwenburgh, C C Appeldoorn, T J Molenaar, T J Van Berkel, and E A Biessen, “Blocking endothelial adhesion molecules: a potential therapeutic strategy to combat atherogenesis,” Current Opinion in Lipidology, vol. 15, no. 5, pp. 545–552, 2004. View at Publisher · View at Google Scholar
  44. L McGregor, J Martin, and J L McGregor, “Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis,” Frontiers in Bioscience, vol. 11, pp. 830–837, 2006. View at Publisher · View at Google Scholar