Clinical Potential of Quantum Dots

Iga, Arthur M.; Robertson, John H. P.; Winslet, Marc C.; Seifalian, Alexander M.

doi:https://doi.org/10.1155/2007/76087

BioMed Research International

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Biomedical Applications of Colloidal Nanocrystals

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Volume 2007 | Article ID 076087 | https://doi.org/10.1155/2007/76087

Clinical Potential of Quantum Dots

Arthur M. Iga,^1,2John H. P. Robertson,²Marc C. Winslet,^2,3and Alexander M. Seifalian^1,4

Academic Editor: Marek Osinski

Received12 Mar 2007

Revised27 Jul 2007

Accepted13 Dec 2007

Published20 Feb 2008

Abstract

Advances in nanotechnology have led to the development of novel fluorescent probes called quantum dots. Quantum dots have revolutionalized the processes of tagging molecules within research settings and are improving sentinel lymph node mapping and identification in vivo studies. As the unique physical and chemical properties of these fluorescent probes are being unraveled, new potential methods of early cancer detection, rapid spread and therapeutic management, that is, photodynamic therapy are being explored. Encouraging results of optical and real time identification of sentinel lymph nodes and lymph flow using quantum dots in vivo models are emerging. Quantum dots have also superseded many of the limitations of organic fluorophores and are a promising alternative as a research tool. In this review, we examine the promising clinical potential of quantum dots, their hindrances for clinical use and the current progress in abrogating their inherent toxicity.

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Copyright © 2007 Arthur M. Iga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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