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Journal of Biomedicine and Biotechnology
Volume 2007, Article ID 84965, 8 pages
http://dx.doi.org/10.1155/2007/84965
Research Article

Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid

1Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Belgrade 11000, Serbia
2Faculty of Technical Sciences, University of Kragujevac, Čačak 32000, Serbia

Received 28 March 2007; Accepted 29 June 2007

Academic Editor: Marek Osinski

Copyright © 2007 Magdalena M. Stevanović et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Ebbesen and T. G. Jensen, “Nanomedicine: techniques, potentials, and ethical implications,” Journal of Biomedicine and Biotechnology, vol. 2006, Article ID 51516, 11 pages, 2006. View at Publisher · View at Google Scholar
  2. T. Yokoyama and C. C. Huang, “Nanoparticle technology for the production of functional materials,” KONA, Powder and Particle, no. 23, pp. 7–17, 2005. View at Google Scholar
  3. C. Thomasin, H. P. Merkle, and B. A. Gander, “Physicochemical parameters governing protein microencapsulation into biodegradable polyesters by coacervation,” International Journal of Pharmaceutics, vol. 147, no. 2, pp. 173–186, 1997. View at Publisher · View at Google Scholar
  4. F. Qian, A. Szymanski, and J. Gao, “Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods,” Journal of Biomedical Materials Research, vol. 55, no. 4, pp. 512–522, 2001. View at Publisher · View at Google Scholar
  5. J. Panyam and V. Labhasetwar, “Biodegradable nanoparticles for drug and gene delivery to cells and tissue,” Advanced Drug Delivery Reviews, vol. 55, no. 3, pp. 329–347, 2003. View at Publisher · View at Google Scholar
  6. I. Bala, S. Hariharan, and M. N. V. Ravi Kumar, “PLGA nanoparticles in drug delivery: the state of the art,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 21, no. 5, pp. 387–422, 2004. View at Publisher · View at Google Scholar
  7. Y. S. Choi, S.-N. Park, and H. Suh, “Adipose tissue engineering using mesenchymal stem cells attached to injectable PLGA spheres,” Biomaterials, vol. 26, no. 29, pp. 5855–5863, 2005. View at Publisher · View at Google Scholar
  8. V. A. Philip, R. C. Mehta, and P. P. DeLuca, “In vitro and in vivo respirable fractions of isopropanol treated PLGA microspheres using a dry powder inhaler,” International Journal of Pharmaceutics, vol. 151, no. 2, pp. 175–182, 1997. View at Publisher · View at Google Scholar
  9. A. L. Daugherty, J. L. Cleland, E. M. Duenas, and R. J. Mrsny, “Pharmacological modulation of the tissue response to implanted polylactic-co-glycolic acid microspheres,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 44, no. 1, pp. 89–102, 1997. View at Publisher · View at Google Scholar
  10. Y.-I. Jeong, J.-G. Song, S.-S. Kang et al., “Preparation of poly(DL-lactide-co-glycolide) microspheres encapsulating all-trans retinoic acid,” International Journal of Pharmaceutics, vol. 259, no. 1-2, pp. 79–91, 2003. View at Publisher · View at Google Scholar
  11. S.-S. Feng, L. Mu, K. Y. Win, and G. Huang, “Nanoparticles of biodegradable polymers for clinical administration of paclitaxel,” Current Medicinal Chemistry, vol. 11, no. 4, pp. 413–424, 2004. View at Publisher · View at Google Scholar
  12. H. Murakami, M. Kobayashi, H. Takeuchi, and Y. Kawashima, “Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method,” International Journal of Pharmaceutics, vol. 187, no. 2, pp. 143–152, 1999. View at Publisher · View at Google Scholar
  13. H. Murakami, M. Kobayashi, H. Takeuchi, and Y. Kawashima, “Further application of a modified spontaneous emulsification solvent diffusion method to various types of PLGA and PLA polymers for preparation of nanoparticles,” Powder Technology, vol. 107, no. 1-2, pp. 137–143, 2000. View at Publisher · View at Google Scholar
  14. M. N. V. Ravi Kumar, U. Bakowsky, and C. M. Lehr, “Preparation and characterization of cationic PLGA nanospheres as DNA carriers,” Biomaterials, vol. 25, no. 10, pp. 1771–1777, 2004. View at Publisher · View at Google Scholar
  15. M. Radić, N. Ignjatović, Z. Nedić, M. Mitrić, D. Miličević, and D. Uskoković, “Synthesis and characterization of biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite,” Materials Science Forum, vol. 494, pp. 537–542, 2005. View at Google Scholar
  16. M. Stevanović, N. Ignjatović, B. Jordović, and D. Uskoković, “Stereological analysis of the poly-(DL-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing,” Journal of Materials Science: Materials in Medicine, vol. 18, no. 7, pp. 1339–1344, 2007. View at Publisher · View at Google Scholar
  17. J. Vandervoort and A. Ludwig, “Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study,” International Journal of Pharmaceutics, vol. 238, no. 1-2, pp. 77–92, 2002. View at Publisher · View at Google Scholar
  18. E. E. Underwood, Quantitative Stereology, Addison-Wesley, Reading, Mass, USA, 1970.
  19. H. E. Exner and H. P. Hougardy, Quantitative Image Analysis of Microstructures, DGM Informationsgesellschaft, Oberursel, Germany, 1988.
  20. M. Kiremitçi-Gümüşderelioǧlu and G. Deniz, “Synthesis, characterization and in vitro degradation of poly (DL-lactide)/poly(DL-lactide-co-glycolide) films,” Turkish Journal of Chemistry, vol. 23, no. 2, pp. 153–162, 1999. View at Google Scholar
  21. W. Lohmann, D. Pagel, and V. Penka, “Structure of ascorbic acid and its biological function. Determination of the conformation of ascorbic acid and isoascorbic acid by infrared and ultraviolet investigations,” European Journal of Biochemistry, vol. 138, no. 3, pp. 479–480, 1984. View at Publisher · View at Google Scholar
  22. A. Grant, T. J. Wilkinson, D. R. Holman, and M. C. Martin, “Identification of recently handled materials by analysis of latent human fingerprints using infrared spectromicroscopy,” Applied Spectroscopy, vol. 59, no. 9, pp. 1182–1187, 2005. View at Publisher · View at Google Scholar