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Journal of Biomedicine and Biotechnology
Volume 2008, Article ID 375620, 7 pages
Research Article

Infectomic Analysis of Gene Expression Profiles of Human Brain Microvascular Endothelial Cells Infected with Cryptococcus neoformans

1Divisions of Hematology-Oncology and Infectious Diseases, Saban Research Institute of Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
2HRL Laboratories, LLC, Malibu, CA 90265, USA
3Department of Life Science, Fu Jen Catholic University, Hsinchuang, Taipei Country 24205, Taiwan

Received 12 August 2007; Accepted 17 December 2007

Academic Editor: Daniel Howard

Copyright © 2008 Ambrose Jong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S.-H. Huang, T. Triche, and A. Jong, “Infectomics: genomics and proteomics of microbial infections,” Functional & Integrative Genomics, vol. 1, no. 6, pp. 331–344, 2002. View at Publisher · View at Google Scholar
  2. T. G. Mitchell and J. R. Perfect, “Cryptococcosis in the era of AIDS—100 years after the discovery of Cryptococcus neoformans,” Clinical Microbiology Reviews, vol. 8, no. 4, pp. 515–548, 1995. View at Google Scholar
  3. M. Gottfredsson and J. R. Perfect, “Fungal meningitis,” Seminars in Neurology, vol. 20, no. 3, pp. 307–322, 2000. View at Publisher · View at Google Scholar
  4. J. R. Perfect, B. Wong, Y. C. Chang, K. J. Kwon-Chung, and P. R. Williamson, “Cryptococcus neoformans: virulence and host defences,” Journal of Medical and Veterinary Mycology, vol. 3, 1, pp. 79–86, 1998. View at Google Scholar
  5. M. Feldmesser, Y. Kress, P. Novikoff, and A. Casadevall, “Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection,” Infection and Immunity, vol. 68, no. 7, pp. 4225–4237, 2000. View at Publisher · View at Google Scholar
  6. T. Bicanic and T. S. Harrison, “Cryptococcal meningitis,” British Medical Bulletin, vol. 72, no. 1, pp. 99–118, 2005. View at Publisher · View at Google Scholar
  7. G. B. Huffnagle and L. K. McNeil, “Dissemination of C. neoformans to the central nervous system: role of chemokines, Th1 immunity and leukocyte recruitment,” Journal of NeuroVirology, vol. 5, no. 1, pp. 76–81, 1999. View at Publisher · View at Google Scholar
  8. L. L. Rubin and J. M. Staddon, “The cell biology of the blood-brain barrier,” Annual Review of Neuroscience, vol. 22, pp. 11–28, 1999. View at Publisher · View at Google Scholar
  9. R. D. Broadwell, B. J. Baker-Cairns, P. M. Friden, C. Oliver, and J. C. Villegas, “Transcytosis of protein through the mammalian cerebral epithelium and endothelium. III. Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin receptor,” Experimental Neurology, vol. 142, no. 1, pp. 47–65, 1996. View at Publisher · View at Google Scholar
  10. S.-H. Huang and A. Jong, “Cellular mechanisms of microbial proteins contributing to invasion of the blood-brain barrier,” Cellular Microbiology, vol. 3, no. 5, pp. 277–287, 2001. View at Publisher · View at Google Scholar
  11. S. H. M. Chen, M. F. Stins, S.-H. Huang et al., “Crytptococcus neoformans induces alterations in cytoskeleton of human rain microvascular endothelial cells,” Journal of Medical Microbiology, vol. 52, pp. 961–970, 2003. View at Publisher · View at Google Scholar
  12. Y. C. Chang, A. Jong, S.-H. Huang, P. Zerfas, and K.J. Kwon-Chung, “CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans,” Infection and Immunity, vol. 74, no. 7, pp. 3930–3938, 2006. View at Publisher · View at Google Scholar
  13. A. Jong, M. F. Stins, S.-H. Huang, S. H. M. Chen, and K. S. Kim, “Traversal of Candida albicansacross human blood-brain barrier in vitro,” Infection and Immunity, vol. 69, no. 7, pp. 4536–4544, 2001. View at Publisher · View at Google Scholar
  14. K. E. Black and L. R. Baden, “Fungal infections of the CNS: treatment strategies for the immunocompromised patient,” CNS Drugs, vol. 21, no. 4, pp. 293–318, 2007. View at Publisher · View at Google Scholar
  15. T. R. Traynor and G. B. Huffnagle, “Role of chemokines in fungal infections,” Medical Mycology, vol. 39, no. 1, pp. 41–50, 2001. View at Publisher · View at Google Scholar
  16. N. Mozaffarian, A. Casadevall, and J. W. Berman, “Inhibition of human endothelial cell chemokine production by the opportunistic fungal pathogen Cryptococcus neoformans,” Journal of Immunology, vol. 165, no. 3, pp. 1541–1547, 2000. View at Google Scholar
  17. A. A. Siddiqui, A. E. Brouwer, V. Wuthiekanun et al., “IFN-? at the site of infection determines rate of clearance of infection in cryptococcal meningitis,” Journal of Immunology, vol. 174, no. 3, pp. 1746–1750, 2005. View at Google Scholar
  18. J. R. Graybill, “Cryptococcal meningitis,” Brazilian Journal of Infectious Diseases, vol. 1, pp. 60–67, 1997. View at Google Scholar