Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways

Figure 3

Trypanothione synthesis in trypanosomatids. The trypanothione producing enzymes are γ-ECS, GS, ODC, aminopropyl transferase (PAT), and TryS. The trypanothione consuming enzymes are ascorbate peroxidase (APX); tryparedoxin peroxidases (TXNPx); trypanothione-glutathione thiol transferase (thiol transferase); and glutathione peroxidases I (GPX I) and II (GPX II). The regenerating enzyme is TryR. APX, thiol transferase, and GPX II have only been described in T. cruzi. This last parasite lacks ODC activity, but it has developed high-affinity transporters for putrescine, cadaverine, and spermidine [71].