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Journal of Biomedicine and Biotechnology
Volume 2008, Article ID 821529, 8 pages
http://dx.doi.org/10.1155/2008/821529
Research Article

Biomarkers and Mechanisms of FANCD2 Function

1Laboratory of Cellular & Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital, Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
2Laboratory of Radiobiology and Experimental Radiation Oncology, University Hospital Eppendorf, University of Hamburg, 20246 Hamburg, Germany
3Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA

Received 26 November 2007; Accepted 25 February 2008

Academic Editor: Lisa Wiesmuller

Copyright © 2008 Henning Willers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. C. Bagby and B. P. Alter, “Fanconi anemia,” Seminars in Hematology, vol. 43, no. 3, pp. 147–156, 2006. View at Google Scholar
  2. R. D. Kennedy and A. D. D'Andrea, “The Fanconi anemia/BRCA pathway: new faces in the crowd,” Genes & Development, vol. 19, no. 24, pp. 2925–2940, 2005. View at Publisher · View at Google Scholar
  3. H. Joenje and K. J. Patel, “The emerging genetic and molecular basis of Fanconi anaemia,” Nature Reviews Genetics, vol. 2, no. 6, pp. 446–457, 2001. View at Publisher · View at Google Scholar
  4. L. J. Niedernhofer, A. S. Lalai, and J. H. J. Hoeijmakers, “Fanconi anemia (cross)linked to DNA repair,” Cell, vol. 123, no. 7, pp. 1191–1198, 2005. View at Publisher · View at Google Scholar
  5. W. Wang, “Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins,” Nature Reviews Genetics, vol. 8, no. 10, pp. 735–748, 2007. View at Publisher · View at Google Scholar
  6. K. J. Patel, “Fanconi anemia and breast cancer susceptibility,” Nature Genetics, vol. 39, no. 2, pp. 142–143, 2007. View at Publisher · View at Google Scholar
  7. A. Smogorzewska, S. Matsuoka, P. Vinciguerra et al., “Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair,” Cell, vol. 129, no. 2, pp. 289–301, 2007. View at Publisher · View at Google Scholar
  8. I. Garcia-Higuera, T. Taniguchi, S. Ganesan et al., “Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway,” Molecular Cell, vol. 7, no. 2, pp. 249–262, 2001. View at Publisher · View at Google Scholar
  9. B. C. Godthelp, W. W. Wiegant, Q. Waisfisz et al., “Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 594, no. 1-2, pp. 39–48, 2006. View at Publisher · View at Google Scholar
  10. S. Houghtaling, C. Timmers, M. Noll et al., “Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice,” Genes & Development, vol. 17, no. 16, pp. 2021–2035, 2003. View at Publisher · View at Google Scholar
  11. R. S. Tebbs, J. M. Hinz, N. A. Yamada et al., “New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant,” DNA Repair, vol. 4, no. 1, pp. 11–22, 2005. View at Publisher · View at Google Scholar
  12. X. Wang, P. R. Andreassen, and A. D. D'Andrea, “Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin,” Molecular and Cellular Biology, vol. 24, no. 13, pp. 5850–5862, 2004. View at Publisher · View at Google Scholar
  13. M. Digweed, S. Rothe, I. Demuth et al., “Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia,” Carcinogenesis, vol. 23, no. 7, pp. 1121–1126, 2002. View at Publisher · View at Google Scholar
  14. K. Nakanishi, Y.-G. Yang, A. J. Pierce et al., “Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 4, pp. 1110–1115, 2005. View at Publisher · View at Google Scholar
  15. A. Lyakhovich and J. Surralles, “Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer,” Cancer Letters, vol. 232, no. 1, pp. 99–106, 2006. View at Publisher · View at Google Scholar
  16. R. D. Kennedy and A. D. D'Andrea, “DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes,” Journal of Clinical Oncology, vol. 24, no. 23, pp. 3799–3808, 2006. View at Publisher · View at Google Scholar
  17. G. Pagano and H. Youssoufian, “Fanconi anaemia proteins: major roles in cell protection against oxidative damage,” BioEssays, vol. 25, no. 6, pp. 589–595, 2003. View at Publisher · View at Google Scholar
  18. T. Takeuchi and K. Morimoto, “Increased formation of 8-hydroxydeoxyguanosine, an oxidative DNA damage, in lymphoblasts from Fanconi's anemia patients due to possible catalase deficiency,” Carcinogenesis, vol. 14, no. 6, pp. 1115–1120, 1993. View at Publisher · View at Google Scholar
  19. H. Joenje, F. Arwert, A. W. Eriksson, H. de Koning, and A. B. Oostra, “Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia,” Nature, vol. 290, no. 5802, pp. 142–143, 1981. View at Publisher · View at Google Scholar
  20. B. Dallapicola, B. Porfirio, V. Mokini, G. Alimena, G. Isacchi, and E. Gandini, “Effect of oxidants and antioxidants on chromosomal breakage in Fanconi anemia lymphocytes,” Human Genetics, vol. 69, no. 1, pp. 62–65, 1985. View at Publisher · View at Google Scholar
  21. H. Saito, A. T. Hammond, and R. E. Moses, “Hypersensitivity to oxygen is a uniform and secondary defect in Fanconi anemia cells,” Mutation Research/DNA Repair, vol. 294, no. 3, pp. 255–262, 1993. View at Publisher · View at Google Scholar
  22. R. C. Cumming, J. Lightfoot, K. Beard, H. Youssoufian, P. J. O'brien, and M. Buchwald, “Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1,” Nature Medicine, vol. 7, no. 7, pp. 814–820, 2001. View at Publisher · View at Google Scholar
  23. S. R. Fagerlie, T. Koretsky, B. Torok-Storb, and G. C. Bagby, “Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc/ mice,” Journal of Immunology, vol. 173, no. 6, pp. 3863–3870, 2004. View at Google Scholar
  24. M. R. Saadatzadeh, K. Bijangi-Vishehsaraei, P. Hong, H. Bergmann, and L. S. Haneline, “Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway,” Journal of Biological Chemistry, vol. 279, no. 16, pp. 16805–16812, 2004. View at Publisher · View at Google Scholar
  25. Q. Pang, T. A. Christianson, W. Keeble et al., “The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality,” Blood, vol. 98, no. 5, pp. 1392–1401, 2001. View at Publisher · View at Google Scholar
  26. S.-J. Park, S. L. M. Ciccone, B. D. Beck et al., “Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins,” Journal of Biological Chemistry, vol. 279, no. 29, pp. 30053–30059, 2004. View at Google Scholar
  27. S. S. Mukhopadhyay, K. S. Leung, M. J. Hicks, P. J. Hastings, H. Youssoufian, and S. E. Plon, “Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia,” Journal of Cell Biology, vol. 175, no. 2, pp. 225–235, 2006. View at Publisher · View at Google Scholar
  28. G. Pagano, P. Degan, M. D'Ischia et al., “Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype,” European Journal of Haematology, vol. 75, no. 2, pp. 93–100, 2005. View at Publisher · View at Google Scholar
  29. P. M. Jakobs, P. Sahaayaruban, H. Saito et al., “Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure,” Somatic Cell and Molecular Genetics, vol. 22, no. 2, pp. 151–157, 1996. View at Publisher · View at Google Scholar
  30. K. Borgmann, B. Röper, R. A. El-Awady et al., “Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations,” Radiotherapy and Oncology, vol. 64, no. 2, pp. 141–152, 2002. View at Publisher · View at Google Scholar
  31. I. Bae, S. Fan, Q. Meng et al., “BRCA1 induces antioxidant gene expression and resistance to oxidative stress,” Cancer Research, vol. 64, no. 21, pp. 7893–7909, 2004. View at Publisher · View at Google Scholar
  32. A. Barzilai, G. Rotman, and Y. Shiloh, “ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage,” DNA Repair, vol. 1, no. 1, pp. 3–25, 2002. View at Publisher · View at Google Scholar
  33. T. Taniguchi, I. Garcia-Higuera, B. Xu et al., “Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways,” Cell, vol. 109, no. 4, pp. 459–472, 2002. View at Publisher · View at Google Scholar
  34. I. M. Ward and J. Chen, “Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress,” Journal of Biological Chemistry, vol. 276, no. 51, pp. 47759–47762, 2001. View at Publisher · View at Google Scholar
  35. T. Tanaka, H. D. Halicka, X. Huang, F. Traganos, and Z. Darzynkiewicz, “Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants,” Cell Cycle, vol. 5, no. 17, pp. 1940–1945, 2006. View at Google Scholar
  36. C. Timmers, T. Taniguchi, J. Hejna et al., “Positional cloning of a novel Fanconi anemia gene, FANCD2,” Molecular Cell, vol. 7, no. 2, pp. 241–248, 2001. View at Publisher · View at Google Scholar
  37. P. Johnstone, C. Reifsteck, S. Kohler, P. Worland, S. Olson, and R. E. Moses, “Fanconi anemia group A and D cell lines respond normally to inhibitors of cell cycle regulation,” Somatic Cell and Molecular Genetics, vol. 23, no. 6, pp. 371–377, 1997. View at Publisher · View at Google Scholar
  38. V. Kuhnert, L. Kachnic, L. Li et al., “The role of FANCD2 in determining cellular resistance to ionizing radiation,” International Journal of Radiation Oncology Biology Physics, vol. 69, no. 3, supplement 1, pp. S594–S595, 2007. View at Publisher · View at Google Scholar
  39. A. Ridet, C. Guillouf, E. Duchaud et al., “Deregulated apoptosis is a hallmark of the Fanconi anemia syndrome,” Cancer Research, vol. 57, no. 9, pp. 1722–1730, 1997. View at Google Scholar
  40. K. Burkitt and M. Ljungman, “Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines,” Cancer Letters, vol. 253, no. 1, pp. 131–137, 2007. View at Publisher · View at Google Scholar
  41. A. D. D'Andrea, “Cellular function of the Fanconi anemia pathway,” Nature Medicine, vol. 7, pp. 1259–1260, 2001. View at Publisher · View at Google Scholar
  42. X. Wang, R. D. Kennedy, K. Ray, P. Stuckert, T. Ellenberger, and A. D. D'Andrea, “Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway,” Molecular and Cellular Biology, vol. 27, no. 8, pp. 3098–3108, 2007. View at Publisher · View at Google Scholar
  43. N. Matsushita, H. Kitao, M. Ishiai et al., “A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair,” Molecular Cell, vol. 19, no. 6, pp. 841–847, 2005. View at Publisher · View at Google Scholar
  44. A. L. Medhurst, El. H. Laghmani, J. Steltenpool et al., “Evidence for subcomplexes in the Fanconi anemia pathway,” Blood, vol. 108, no. 6, pp. 2072–2080, 2006. View at Publisher · View at Google Scholar
  45. E. P. Rogakou, W. Nieves-Neira, C. Boon, Y. Pommier, and W. M. Bonner, “Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139,” Journal of Biological Chemistry, vol. 275, no. 13, pp. 9390–9395, 2000. View at Publisher · View at Google Scholar
  46. O. A. Sedelnikova, I. Horikawa, C. Redon et al., “Delayed kinetics of DNA double-strand break processing in normal and pathological aging,” Aging Cell, vol. 7, no. 1, pp. 89–100, 2008. View at Publisher · View at Google Scholar