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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 406136, 6 pages
http://dx.doi.org/10.1155/2009/406136
Research Article

Variable Increased Expression of Program Death-1 and Program Death-1 Ligands on Peripheral Mononuclear Cells Is Not Impaired in Patients with Systemic Lupus Erythematosus

Section of Rheumatology and Immunology, Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan 704, Taiwan

Received 9 February 2009; Revised 16 June 2009; Accepted 27 June 2009

Academic Editor: Robert E. Cone

Copyright © 2009 Ming-Fei Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Greenwald, G. J. Freeman, and A. H. Sharpe, “The B7 family revisited,” Annual Review of Immunology, vol. 23, pp. 515–548, 2005. View at Publisher · View at Google Scholar
  2. T. Okazaki, Y. Iwai, and T. Honjo, “New regulatory co-receptors: inducible co-stimulator and PD-1,” Current Opinion in Immunology, vol. 14, no. 6, pp. 779–782, 2002. View at Publisher · View at Google Scholar
  3. G. J. Freeman, A. J. Long, Y. Iwai et al., “Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation,” Journal of Experimental Medicine, vol. 192, no. 7, pp. 1027–1034, 2000. View at Publisher · View at Google Scholar
  4. Y. Latchman, C. R. Wood, T. Chernova et al., “PD-L2 is a second ligand for PD-1 and inhibits T cell activation,” Nature Immunology, vol. 2, no. 3, pp. 261–268, 2001. View at Publisher · View at Google Scholar
  5. H. Nishimura, N. Minato, T. Nakano et al., “Immunological studies on PD-1-deficient mice: implication of PD-1 as a negative regulator for B cell responses,” International Immunology, vol. 10, no. 10, pp. 1563–1572, 1998. View at Publisher · View at Google Scholar
  6. H. Nishimura, M. Nose, H. Hiai et al., “Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor,” Immunity, vol. 11, no. 2, pp. 141–151, 1999. View at Publisher · View at Google Scholar
  7. H. Nishimura, T. Okazaki, and Y. Tanaka , “Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice,” Science, vol. 291, no. 12, pp. 319–322, 2001. View at Google Scholar
  8. M. J. I . Ansari, A. D. Salama, T. Chitnis et al., “The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice,” Journal of Experimental Medicine, vol. 198, no. 1, pp. 63–69, 2003. View at Publisher · View at Google Scholar
  9. A. D. Salama, T. Chitnis, J. Imitola et al., “Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis,” Journal of Experimental Medicine, vol. 198, no. 1, pp. 71–78, 2003. View at Publisher · View at Google Scholar
  10. S. Hatachi, Y. Iwai, S. Kawano et al., “CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid,” Journal of Rheumatology, vol. 30, no. 7, pp. 1410–1419, 2003. View at Google Scholar
  11. T. Kanai, T. Totsuka, K. Uraushihara et al., “Blockade of B7-H1 suppresses the development of chronic intestinal inflammation,” Journal of Immunology, vol. 171, no. 8, pp. 4156–4163, 2003. View at Google Scholar
  12. E. M. Tan, A. S. Cohen, and J. F. Fries, “The 1982 revised criteria for the classification of systemic Lupus erythematosus,” Arthritis RheumLupus, vol. 25, no. 5, pp. 1271–1277, 1982. View at Google Scholar
  13. S. C. Liang, Y. E. Latchman, J. E. Buhlmann et al., “Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses,” European Journal of Immunology, vol. 33, no. 10, pp. 2706–2716, 2003. View at Publisher · View at Google Scholar
  14. T. Yamazaki, H. Akiba, H. Iwai et al., “Expression of programmed death 1 ligands by murine T cells and APC,” Journal of Immunology, vol. 169, no. 10, pp. 5538–5545, 2002. View at Google Scholar
  15. M. Ishida, Y. Iwai, Y. Tanaka et al., “Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues,” Immunology Letters, vol. 84, no. 1, pp. 57–62, 2002. View at Publisher · View at Google Scholar
  16. M. J. Eppihimer, J. Gunn, G. J. Freeman et al., “Expression and regulation of the PD-L1 immunoinhibitory molecule on micro vascular endothelial cells,” Microcirculation, vol. 9, no. 2, pp. 133–145, 2002. View at Publisher · View at Google Scholar
  17. R. Schoop, P. Wahl, M. Le Hir et al., “Suppressed T-cell activation by INF-?-induced expression of PD-L1 on renal tubular epithelial cells,” Nephrology Dialysis Transplantation, vol. 19, no. 11, pp. 2713–2720, 2004. View at Publisher · View at Google Scholar
  18. A. Nakazawa, I. Dotan, J. Brimnes et al., “The expression and function of costimulatory molecules B7h and B7-H1 on colonic epithelial cells,” Gastroenterology, vol. 126, no. 5, pp. 1347–1357, 2004. View at Publisher · View at Google Scholar
  19. M. E. Keir, S. C. Liang, I. Guleria et al., “Tissue expression of PD-L1 mediates peripheral T cell tolerance,” Journal of Experimental Medicine, vol. 203, no. 4, pp. 883–895, 2006. View at Publisher · View at Google Scholar
  20. S. Hatachi, Y. Iwai, S. Kawano et al., “CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid,” Journal of Rheumatology, vol. 30, no. 7, pp. 1410–1419, 2003. View at Google Scholar
  21. M. Kobayashi, K. Seiji, H. Saori et al., “Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome,” Journal of Rheumatology, vol. 32, no. 11, pp. 2156–2163, 2005. View at Google Scholar
  22. Y. Tsutsumi, K. Ihara, A. Nomura et al., “Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with type-1 diabetes,” Diabetic Medicine, vol. 23, pp. 1145–1150, 2006. View at Google Scholar
  23. P. Youngnak-Piboonratanakit, F. Tsushima, N. Otsuki et al., “The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role,” Immunology Letters, vol. 94, no. 3, pp. 215–222, 2004. View at Publisher · View at Google Scholar
  24. M. J. I. Ansari, A. D. Salama, T. Chitnis et al., “The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice,” Journal of Experimental Medicine, vol. 198, no. 1, pp. 63–69, 2003. View at Publisher · View at Google Scholar
  25. A. D. Salama, T. Chitnis, J. Imitola, H. Akiba, F. Tushima, and M. Azuma, “Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis,” Journal of Experimental Medicine, vol. 198, no. 1, pp. 71–78, 2003. View at Publisher · View at Google Scholar
  26. T. Kanai, T. Totsuka, K. Uraushihara et al., “Blockade of B7-H1 suppresses the development of chronic intestinal inflammation,” Journal of Immunology, vol. 171, no. 8, pp. 4156–4163, 2003. View at Google Scholar
  27. P. Loke and J. P. Allison, “PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 9, pp. 5336–5341, 2003. View at Publisher · View at Google Scholar