Immune Responses Following Mouse Peripheral Nerve Xenotransplantation in Rats

Figure 2

Rapid and progressive loss of axons in mouse nerve xenografts. Autologous (a)–(c) and xenogeneic mouse (d)–(f) nerve grafts were harvested at weeks 2 (a) and (d), 4 (b) and (e), and 8 (c) and (f) posttransplantation and analyzed by immunohistochemistry with S-100 staining. Five rats per group were examined at each time point (these are the same animals shown in Figure 1), and representative samples (𝑥40) are shown. NF, nerve fibers.

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