Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy

Figure 8

Histopathology and immunohistochemistry of a re-challenge tumor. (a) A low-power view of a re-challenge tumor with HE staining (×40). (b) A high-power view (×200). Monocytic infiltrates are seen around a necrotic lesion. (c) CD4⁺ T cells (×400). (d) CD8⁺T cells (×400). Almost equal numbers of CD4⁺ and CD8⁺ T cells are observed.

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