Investigating Topological and Functional Features of Multimodular Proteins

Table 3

Comparison between top 100 most frequent multimodular proteins and most frequent “bottle neck” proteins, identified by Przulj et al. (2003).

Module freq.	≥2.1		≥1.9		≥1.8		≥1.7
“bottle necks”		≥25		≥18		≥14		≥11
[#] Proteins	[25]		[50]		[75]		[100]
GO biological Process	GO term frequency
	P value
Cellular process (64.1%)	—	100%	—	98%	93%	95%	—	94%
		5.1⋅10^−3		2.5⋅10^−5	1.0⋅10^−6	2.0⋅10^−7		9.7⋅10^−10
Ribonucleoprotein complex biogenesis and assembly (5.5%)	40%	−−−	42%	32%	39%	27%	36%	25%
	5.6⋅10^−5		9.3⋅10^−18	1.9⋅10^−6	1.7⋅10^−15	1.0⋅10^−6	3.2⋅10^−18	4.8⋅10^−8
Cellular component organization and biogenesis (30%)	—	—	70%	66%	63%	61%	62%	63%
			1.7⋅10^−06	6.3⋅10^−5	1.5⋅10^−6	9.2⋅10^−6	1.2⋅10^−8	4.2⋅10^−9
Organelle organization and biogenesis (17.8%)	—	—	50%	46%	48%	43%	45%	43%
			5.8⋅10^−5	1.6⋅10^−3	5.7⋅10^−7	2.2⋅10^−4	1.0⋅10^−7	2.0⋅10^−6
Cellular metabolic process (46.6%)	—	—	—	76%	79%	79%	81%	77%
				8.6⋅10^−3	3.6⋅10^−6	5.9⋅10^−6	4.7⋅10^−10	2.4⋅10^−7
RNA metabolic process (14.2%)	—	—	48%	—	52%	35%	48%	32%
			1.8⋅10^−13		2.8⋅10^−12	3.4⋅10^−3	1.8⋅10^−13	2.4⋅10^−3
Primary metabolic process (44%)	—	—	79%	—	79%	73%	79%	73%
			2.1⋅10^−10		2.7⋅10^−7	1.2⋅10^−4	2.1⋅10^−10	2.0⋅10^−6