BioMed Research International / 2009 / Article / Tab 1

Research Article

High Specificity of Quantitative Methylation-Specific PCR Analysis for MGMT Promoter Hypermethylation Detection in Gliomas

Table 1

MGMT methylation frequencies in normal brain tissues and glioma samples.

MGMT * statusNormal brain tissues FFPE samples#    Frozen samples Total tumour samples
QMSPMSPQMSPMSPQMSPMSPQMSPMSP

neg26 (92.9%)18 (64.3%)13 (46.4%)15 (53.6%)8 (36.4%)7 (31.8%)21 (42.0%)22 (44.0%)
pos2 (7.1%)10 (35.7%)15 (53.6%)13 (46.4%)14 (63.6%)15 (68.2%)29 (58.0%)28 (56.0%)

*neg: Methylation levels for QMSP are below the cutoff point of 0.35, no band is seen in gel electrophoresis for MSP; pos: Methylation levels for QMSP exceed the cutoff point of 0.35, a band is seen in gel electrophoresis for MSP. #FFPE: Formalin-fixed paraffin-embedded.

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