BioMed Research International / 2009 / Article / Tab 3

Research Article

High Specificity of Quantitative Methylation-Specific PCR Analysis for MGMT Promoter Hypermethylation Detection in Gliomas

Table 3

Comparison of MGMT methylation status as determined by Quantitative Methylation-Specific PCR (QMSP) and. Methylation-Specific PCR (MSP).

NBT* FFPE* SF* Tumours* Total samples*
MSP +MSP-MSP +MSP-MSP +MSP-MSP +MSP-MSP +MSP-

QMSP<0.35818013353181136
>0.3520132122254274

0.2430.8600.4950.7150.613
95%CI0.084–0.400.73–0.990.286–0.7040.59–0.840.505–0.712
.049 .0001 .0001

*NBT: Normal brain tissue; FFPE: Formalin fixed paraffin embedded specimens, SF: Snap-frozen specimen; MSP +: A band is seen in gel electrophoresis; -: No band is seen in gel electrophoresis. # :  Measure of the degree of concordance between MSP and QMSP (see Materials and Methods), 95%CI, Confidence interval.

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