YQ36: A Novel Bisindolylmaleimide Analogue Induces KB/VCR Cell Death

Table 1

The IC₅₀ values of YQ36 and DOX on three panels of chemosensitive tumor cell line and their chemoresistance subline. The fold indicated the index of IC₅₀ on chemoresistance subline versus chemosensitive cell line.

Cell lines	IC50 (𝜇M)
	YQ36	Fold	Doxorubicin	Fold
KB	5.80 ± 0.39	0.82	4.35 ± 0.16	6.60
KB/VCR	4.78 ± 0.66		28.69 ± 1.87
MCF-7	15.68 ± 1.41	0.50	29.76 ± 1.48	4.49
MCF-7/DOR	7.90 ± 0.73		133.48 ± 13.95
K562	5.64 ± 1.40	2.28	3.06 ± 0.04	4.47
K562/ADR	12.86 ± 1.97		13.68 ± 1.03