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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 595126, 8 pages
http://dx.doi.org/10.1155/2009/595126
Research Article

Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

Received 21 June 2009; Accepted 1 September 2009

Academic Editor: Jeffrey Hughes

Copyright © 2009 Mei Dai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. S. Atiyeh and S. N. Hayek, “An update on management of acute and chronic open wounds: the importance of moist environment in optimal wound healing,” Medicinal Chemistry Reviews-Online, vol. 1, pp. 111–121, 2004. View at Google Scholar
  2. L. Suguna, S. Singh, P. Sivakumar, P. Sampath, and G. Chandrakasan, “Influence of Terminalia chebula on dermal wound healing in rats,” Phytotherapy Research, vol. 16, no. 3, pp. 227–231, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Ueno, T. Mori, and T. Fujinaga, “Topical formulations and wound healing applications of chitosan,” Advanced Drug Delivery Reviews, vol. 52, no. 2, pp. 105–115, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Qin, “Alginate fibres: an overview of the production processes and applications in wound management,” Polymer International, vol. 57, no. 2, pp. 171–180, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Ueno, H. Yamada, I. Tanaka et al., “Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs,” Biomaterials, vol. 20, no. 15, pp. 1407–1414, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. H. L. Lai, A. Abu'Khalil, and D. Q. M. Craig, “The preparation and characterisation of drug-loaded alginate and chitosan sponges,” International Journal of Pharmaceutics, vol. 251, no. 1-2, pp. 175–181, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Ma, W. Yu, and X. Ma, “Preparation and characterization of novel sodium alginate/chitosan two ply composite membranes,” Journal of Applied Polymer Science, vol. 106, no. 1, pp. 394–399, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. G. C. Jagetia and B. B. Aggarwal, ““Spicing up” of the immune system by curcumin,” Journal of Clinical Immunology, vol. 27, no. 1, pp. 19–35, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Brouet and H. Ohshima, “Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages,” Biochemical and Biophysical Research Communications, vol. 206, no. 2, pp. 533–540, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. E.-M. Strasser, B. Wessner, N. Manhart, and E. Roth, “The relationship between the anti-inflammatory effects of curcumin and cellular glutathione content in myelomonocytic cells,” Biochemical Pharmacology, vol. 70, no. 4, pp. 552–559, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Han and Y. Yang, “Antimicrobial activity of wool fabric treated with curcumin,” Dyes and Pigments, vol. 64, no. 2, pp. 157–161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. O. Vajragupta, P. Boonchoong, G. M. Morris, and A. J. Olson, “Active site binding modes of curcumin in HIV-1 protease and integrase,” Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 14, pp. 3364–3368, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Chai, S. Yan, P. Lin, A. B. Lumsden, Q. Yao, and C. Chen, “Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries,” Journal of the American College of Surgeons, vol. 200, no. 6, pp. 820–830, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. B. B. Aggarwal, A. Kumar, and A. C. Bharti, “Anticancer potential of curcumin: preclinical and clinical studies,” Anticancer Research, vol. 23, no. 1A, pp. 363–398, 2003. View at Google Scholar · View at Scopus
  15. E. O. Farombi and M. Ekor, “Curcumin attenuates gentamicin-induced renal oxidative damage in rats,” Food and Chemical Toxicology, vol. 44, no. 9, pp. 1443–1448, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. S.-Y. Park, H.-S. Kim, E.-K. Cho et al., “Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation,” Food and Chemical Toxicology, vol. 46, no. 8, pp. 2881–2887, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Motterlini, R. Foresti, R. Bassi, and C. J. Green, “Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress,” Free Radical Biology and Medicine, vol. 28, no. 8, pp. 1303–1312, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Duvoix, R. Blasius, S. Delhalle et al., “Chemopreventive and therapeutic effects of curcumin,” Cancer Letters, vol. 223, no. 2, pp. 181–190, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Sreepriya and G. Bali, “Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats,” Fitoterapia, vol. 76, no. 6, pp. 549–555, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Khafif, R. Hurst, K. Kyker, D. M. Fliss, Z. Gil, and J. E. Medina, “Curcumin: a new radio-sensitizer of squamous cell carcinoma cells,” Otolaryngology—Head and Neck Surgery, vol. 132, no. 2, pp. 317–321, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Kapoor and K. I. Priyadarsini, “Protection of radiation-induced protein damage by curcumin,” Biophysical Chemistry, vol. 92, no. 1-2, pp. 119–126, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Panchatcharam, S. Miriyala, V. S. Gayathri, and L. Suguna, “Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species,” Molecular and Cellular Biochemistry, vol. 290, no. 1-2, pp. 87–96, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. T.-T. Phan, P. See, S.-T. Lee, and S.-Y. Chan, “Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing,” Journal of Trauma, vol. 51, no. 5, pp. 927–931, 2001. View at Google Scholar · View at Scopus
  24. D. Gopinath, M. R. Ahmed, K. Gomathi, K. Chitra, P. K. Sehgal, and R. Jayakumar, “Dermal wound healing processes with curcumin incorporated collagen films,” Biomaterials, vol. 25, no. 10, pp. 1911–1917, 2004. View at Publisher · View at Google Scholar · View at Scopus