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Journal of Biomedicine and Biotechnology
Volume 2009 (2009), Article ID 617509, 8 pages
http://dx.doi.org/10.1155/2009/617509
Research Article

Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

1Key Laboratory of Zoonosis, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Ministry of Education, Changchun 130062, China
2Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China

Received 1 December 2008; Revised 21 May 2009; Accepted 28 June 2009

Academic Editor: Daniele Daffonchio

Copyright © 2009 Haihua Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT.