Review Article

MicroRNA Implications across Neurodevelopment and Neuropathology

Table 1

miRNAs involved in neurodevelopment.

miRNASpeciesTargetFunctionReference number

miR-iab-4-5pDrosophilaUBXRegulation of Hox gene involved in the development of halters[34]
miR10aHumanHOXA1Downregulation of HOXA1 geneExpression[35]
lsy-6C. elegansCog-1Required to specify ASEL sensory neuron identity[36, 37]
miR-273C. elegansDie-1Expressed in ASER; suppresses ASEL identity[36, 38]
miR-196RodentsHOXB8Downregulation of HOXC8, HOXD8 and HOXA7[39]
miR-124RodentsSCP1Neural induction in the spinal cord of developing embryos[40]
miR-124RodentsSOX9Regulation of the neurogenesis in the SVZ stem cell niche and neurite outgrowth in neuronal differentiation[41]
miR-132RodentsP250GAPRegulation of the neuronal morphogenesis and circadian clock[42, 43]
miR-219RodentsSCOPRegulation of the circadian period length[36, 43]
miR-133bRodentsPitx3Regulation of the maturation of midbrain dopaminergic neurons[44]
miR-134RodentsLimK1Modulation of the size of dendritic spines[45]