A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples

Table 1

Lower limit of quantification.

	Analyte concentration (ng/mL)		0.990
	Conc. (ng/mL)	% nominal	Signal/noise ratio
	0.989	99.945	44.500
	1.407	142.094	36.000
	0.958	96.802	46.100
	1.167	117.863	31.700
	1.175	118.723	41.500
	1.241	125.400	48.800
N	6	6	6
Mean	1.156	116.804	41.433
SD (±)	0.166
CV(%)	14.339
	Acceptance criteria
	4 out of 6 LLQC must be 100±20% nominal value.
	Mean % nominal 100±20%
	CV (%) ≤ 20%
	Signal/noise ratio ≥ 5