Research Article
Genetic Polymorphisms in the EGFR (R521K) and Estrogen Receptor (T594T) Genes, EGFR and ErbB-2 Protein Expression, and Breast Cancer Risk in Tunisia
Table 2
Allelic and genotype distribution frequencies of R521K and T594T polymorphism in the patients and the control groups.
| | Polymorphism | | Genotypes | | Alleles (%) | | AA | AG | GG | A | G |
| | EGFR R521K | | | | | | | Cases () | 12 | 46 | 90 | 70 (23.6) | 226 (76.3) | | Controls () | 26 | 103 | 174 | 155 (25.6) | 451 (74.4) | | AA versus GG | AA versus AG | AA versus (AG + GG) | A versus G | | Odds ratio | 1.12 | 0.97 | 1.06 | 1.110 | | (95%CI) | [0.54–2.17] | [0.45–2.08] | [0.52–2.17] | [0.80–1.53] | | Chi-square (-value) | .09 (.76) | .01 (.93) | .03 (.86) | .40 (.52) |
| | ESR1 T594T | | | | | | | Cases () | 5 | 36 | 101 | 46 (16.3) | 236 (83.7) | | Controls () | 17 | 76 | 147 | 110 (22.9) | 370 (77.1) | | AA versus GG | AA versus AG | (AG + AA) versus GG | A versus G | | Odds ratio | 2.33 | 1.61 | 1.56 | 1.54 | | (95%CI) | [0.83–6.53] | [0.55–4.71] | [1–2.44] | [1.05–2.25] | | Chi-square (-value) | 2.75 (.10) | .77 (.38) | 3.812 (.05) | 4.96 (.025) |
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