In Vitro Ultramorphological Assessment of Apoptosis Induced by Zerumbone on (HeLa)
SEM micrographs of surface ultrastructural characteristics of HeLa cells treated with ZER in time-dependent manner (0, 24, 48, and 72 hours) and cultured in RPMI 1640 media maintained at 37 and 5% CO2. (a) The characteristic of untreated HeLa cells surface showing the restoration of a typical morphological feature of a cancer cell such as numerous microvilli (as shown in grey arrow) with several membrane connections. (b), (c), and (d) ZER-treated HeLa cells (24, 48, and 72 hours, IC50: 20.41 μM) showed distinct morphological changes corresponding to typical apoptosis, including cell membrane blebbing (b), microvilli disappearance or reduction (blunt microvillus (s)), and separated apoptotic bodies (X2500).
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