BioMed Research International / 2009 / Article / Tab 1

Research Article

DNA Damage/Repair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients

Table 1

Repair of hydrogen peroxide-induced DNA damage in 30 AMD patients and 30 healthy controls. DNA damage for each treatment was analyzed as the percentage of DNA in the tail of 100 comets; mean ± S.E.M. The number of cells scored in each treatment (patient) was 100. The efficacy of DNA repair was calculated by comparing the extent of DNA damage immediately and 120 minutes after hydrogen peroxide treatment. The subjects with no significant repair are presented bold.

NoAge (yrs)/SexControl DNA damage ± S.EM.Efficacy of DNA repair (%)PNoAge (yrs)/SexAMD DNA damage ± S.EM.Efficacy of DNA repair (%)

172/W12.19 ± 4.135.62 ± 2.3453.90 .05172/M 7.30 ± 0.881.29 ± 0.2782.33< .001
260/M15.73 ± 2.125.84 ± 1.2362.87< .001260/M 6.43 ± 0.621.44 ± 0.1977.61< .001
381/W15.89 ± 2.099.02 ± 1.4243.24< .01361/M 4.38 ± 0.506.66 ± 0.84 < .05
477/W15.99 ± 2.878.95 ± 2.1544.03> .05464/W 4.85 ± 0.502.00 ± 0.3558.76< .001
559/W12.49 ± 1.905.60 ± 2.9955.17> .05565/M 3.73 ± 0.416.16 ± 1.07 < .05
664/W 9.78 ± 1.244.48 ± 2.1254.19< .05682/W 3.66 ± 0.380.83 ± 0.1777.32< .001
780/W20.01 ± 2.309.34 ± 1.5753.32< .001759/M 7.59 ± 1.376.67 ± 1.37 12.13> .05
860/M12.51 ± 1.384.17 ± 0.4966.67< .001870/M17.57 ± 1.416.66 ± 2.2062.10< .001
973/M 6.89 ± 1.733.26 ± 0.7452.69> .05978/W12.37 ± 1.9210.48 ± 1.97 15.28> .05
1072/W 6.73 ± 0.884.26 ± 0.9836.70> .051079/W 2.51 ± 0.404.04 ± 0.38 < .05
1166/M11.18 ± 2.176.21 ± 1.5344.46> .051173/W 6.26 ± 0.998.33 ± 1.54 > .05
1280/W13.92 ± 4.116.47 ± 2.2153.52> .051260/W 3.19 ± 0.454.46 ± 0.87 > .05
1360/M 8.95 ± 1.462.04 ± 0.4077.21< .0011363/W 6.81 ± 1.143.53 ± 1.93 48.17> .05
1479/W10.11 ± 1.808.76 ± 2.0413.35 .051473/W 3.81 ± 0.613.24 ± 0.39 14.96> .05
1564/W14.52 ± 1.366.13 ± 0.9257.78 .0011570/M 7.41 ± 0.645.14 ± 0.5630.64< .05
1675/M 4.12 ± 0.653.63 ± 0.5811.89 .051674/W 9.40 ± 1.563.15 ± 0.4966.49< .001
1773/W14.63 ± 1.385.19 ± 0.6764.53 .0011775/W 9.59 ± 1.5812.53 ± 1.81 > .05
1869/M18.29 ± 1.286.60 ± 1.1263.92 .051864/M 9.35 ± 1.367.56 ± 0.9719.15> .05
1966/M17.46 ± 4.258.80 ± 1.5849.60 .051977/W 2.14 ± 0.232.48 ± 0.48 > .05
2077/W 18.19 ± 4.168.63 ± 3.2052.56 .052062/W12.00 ± 1.3214.58 ± 0.85 > .05
2175/M 9.55 ± 1.077.05 ± 2.5826.18 .052169/M10.11 ± 0.8017.34 ± 0.89 < .001
2264/M11.31 ± 2.099.35 ± 2.5017.33 .052274/M34.88 ± 2.6526.54 ± 1.4323.91< .01
2370/W13.53 ± 2.187.91 ± 1.5241.54 .052372/M 8.63 ± 0.8918.09 ± 1.23 < .001
2463/W14.39 ± 3.607.41 ± 1.1848.51 .052480/W 34.05 ± 4.3925.75 ± 2.9724.38> .05
2571/M12.32 ± 2.125.31 ± 1.7256.90 .052580/W52.14 ± 3.4119.01 ± 1.7163.54< .001
2672/W 8.37 ± 0.873.67 ± 0.3356.16 .0012669/W12.71 ± 1.2021.93 ± 2.30 < .001
2770/M12.32 ± 2.125.31 ± 1.7256.90 .052772/M 5.14 ± 0.468.13 ± 0.77 < .01
2871/M14.39 ± 2.607.41 ± 1.2848.51 .052869/M17.02 ± 1.5923.14 ± 2.03 < .05
2973/M12.53 ± 2.177.91 ± 1.2236.87 .052973/W18.22 ± 2.7515.72 ± 1.13 13.72> .05
3070/W11.31 ± 2.199.35 ± 2.25 17.33 .053066/M13.48 ± 1.5912.16 ± 1.82 9.79>.05
Mean70 ± 612.65 ± 0.666.46 ± 0.3747.26 ± 2.92Mean70 ± 711.56 ± 1.989.97 ± 1.391.11 ± 9. 56

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