Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats

<table>LTP induction in the medial perforant path—dentate gyrus (MPP-DG) pathway in sensorimotor deprived group (treatment) and sham-operated control group (control) at indicated age. (a) PN25, (b) PN35, (c) PN45, (d) PN60. Arrow indicates the time point when conditioning stimulation was administered. Numbers of rats (<svg height="11.3125" id="M66" style="vertical-align:-0.1092pt" version="1.1" viewbox="0 0 14.9875 11.3125" width="14.9875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) and slices (<svg height="7.9499998" id="M67" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.6625004 7.9499998" width="8.6625004" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) are indicated in all figures. (e) Summary of LTP induction at PN25, PN35, PN45, and PN60. <svg height="17.825001" id="M68" style="vertical-align:-3.27605pt" version="1.1" viewbox="0 0 78.762497 17.825001" width="78.762497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> a highly significant between group difference for a given age (<svg height="11.375" id="M69" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>).</table>

BioMed Research International

fig3

Figure 3

Figure 3: Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats 