Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats
LTP induction in the medial perforant path—dentate gyrus (MPP-DG) pathway in sensorimotor deprived group (treatment) and sham-operated control group (control) at indicated age. (a) PN25, (b) PN35, (c) PN45, (d) PN60. Arrow indicates the time point when conditioning stimulation was administered. Numbers of rats () and slices () are indicated in all figures. (e) Summary of LTP induction at PN25, PN35, PN45, and PN60. a highly significant between group difference for a given age ().
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