Review Article

Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle

Table 1

Strong binding rigor cross-bridges but no cycling cross-bridges affect Ca-binding to troponin C in reconstituted myofilament preparations. Data are from Davis et al. [36].

SystemKd nMHill n Koff(/s)

Thin Filament 4 8 1 0 ± 3 0 0 1 . 6 5 ± 0 . 0 4 1 0 5 + 1
Thin Filament + S1 7 7 7 ± 3 0 0 . 8 1 ± 0 . 0 2 1 3 ± . 1
Thin Filament + S1 + ATP 5 0 4 0 ± 4 0 0 1 . 6 5 ± 0 . 0 8 1 1 0 ± 1