Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation
Insulin recovers mitochondrial respiratory activity, reduced by rA42 oligomers. LAN5 were untreated (control), treated with rA42 oligomers (40 M) for 1 h (oligomers), rA42 oligomers (40 M) for 1 h and insulin (100 M) for 20 h (oligomers + insulin). Cells were incubated with Mito Red and Hoechst 33258. The images of each sample were merged. Red staining indicates mitochondrial activity (see red arrows). Blue staining indicates nuclear fragmentation (see blue arrows).
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