BioMed Research International / 2010 / Article / Fig 4

Research Article

Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation

Figure 4

Insulin recovers mitochondrial respiratory activity, reduced by rA 𝛽 42 oligomers. LAN5 were untreated (control), treated with rA 𝛽 42 oligomers (40  πœ‡ M) for 1 h (oligomers), rA 𝛽 42 oligomers (40  πœ‡ M) for 1 h and insulin (100  πœ‡ M) for 20 h (oligomers + insulin). Cells were incubated with Mito Red and Hoechst 33258. The images of each sample were merged. Red staining indicates mitochondrial activity (see red arrows). Blue staining indicates nuclear fragmentation (see blue arrows).

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