Figure 1: Parasitological and histopathological examination of infected mice treated with or without artesunate. In each experiment, twelve mice were percutaneously infected with S. japonicum and among these mice, six were orally administered artesunate dissolved in dd H 2 O as described in Materials and Methods. At 23, 35, and 56 days mice were sacrificed and perfused to measure the worm and liver egg burdens and for histopathological analysis. (a) Adult worms in the mesenteric veins of infected mice. (b) Egg nodes in the surface of the livers. (c) Microscopic examination of hepatic granulomatous inflammation in liver sections (Magnification: × 400). Measurements were made at 0 d and at three time points postinfection. Each micrograph is representative of three experiments.