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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 203503, 8 pages
http://dx.doi.org/10.1155/2010/203503
Research Article

Physiological and Histopathological Investigations on the Effects of 𝛼 -Lipoic Acid in Rats Exposed to Malathion

Department of Biological Sciences, Faculty of Sciences, King Abdul Aziz University, P.O. Box 139109, Jeddah 21323, Saudi Arabia

Received 16 January 2010; Accepted 7 March 2010

Academic Editor: Wen-Quan Zou

Copyright © 2010 Atef M. Al-Attar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was designed to evaluate the influence of 𝛼 -lipoic acid treatment in rats exposed to malathion. Forty adult male rats were used in this study and distributed into four groups. Animals of group 1 were untreated and served as control. Rats of group 2 were orally given malathion at a dose level of 100 mg/kg body weight (BW) for a period of one month. Experimental animals of group 3 were orally given 𝛼 -lipoic acid at a dose level of 20 mg/kg BW and after 3 hours exposed to malathion at the same dose given to group 2. Rats of group 4 were supplemented with 𝛼 -lipoic acid at the same dose given to group 3. The activities of serum glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), and acid phosphatase (ACP), and the values of creatinine, urea, and uric acid were statistically increased, while the values of total protein and total albumin were significantly decreased in rats exposed to malathion. Moreover, administration of malathion for one month resulted in damage of liver and kidney structures. Administration of 𝛼 -lipoic acid before malathion exposure to rat can prevent severe alterations of hematobiochemical parameters and disruptions of liver and kidney structures. In conclusion, this study obviously demonstrated that pretreatment with 𝛼 -lipoic acid significantly attenuated the physiological and histopathological alterations induced by malathion. Also, the present study identifies new areas of research for development of better therapeutic agents for liver, kidney, and other organs' dysfunctions and diseases.