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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 203503, 8 pages
http://dx.doi.org/10.1155/2010/203503
Research Article

Physiological and Histopathological Investigations on the Effects of 𝛼 -Lipoic Acid in Rats Exposed to Malathion

Department of Biological Sciences, Faculty of Sciences, King Abdul Aziz University, P.O. Box 139109, Jeddah 21323, Saudi Arabia

Received 16 January 2010; Accepted 7 March 2010

Academic Editor: Wen-Quan Zou

Copyright © 2010 Atef M. Al-Attar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Cantelli-Forti, M. Paolini, and P. Hrelia, “Multiple end point procedure to evaluate risk from pesticides,” Environmental Health Perspectives, vol. 101, supplement 3, pp. 15–20, 1993. View at Google Scholar · View at Scopus
  2. K. Chaudhuri, S. Selvaraj, and A. K. Pal, “Studies on the genotoxicity of endosulfan in bacterial systems,” Mutation Research, vol. 439, no. 1, pp. 63–67, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Davis, “Neurotoxic concerns of human pesticide exposures,” American Journal of Industrial Medicine, vol. 18, no. 3, pp. 327–331, 1991. View at Google Scholar
  4. H. J. Mason, “The recovery of plasma cholinesterase and erythrocyte acetylcholinesterase activity in workers after over-exposure to dichlorvos,” Occupational Medicine, vol. 50, no. 5, pp. 343–347, 2000. View at Google Scholar · View at Scopus
  5. H. N. Nigg and J. B. Knaak, “Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure,” Reviews of Environmental Contamination & Toxicology, vol. 163, pp. 29–111, 2000. View at Google Scholar · View at Scopus
  6. R. L. Ridgway, J. C. Tinney, J. T. MacGregor, and N. J. Starler, “Pesticide use in agriculture,” Environmental Health Perspectives, vol. 27, pp. 103–112, 1978. View at Google Scholar · View at Scopus
  7. L. Fishbein, “An overview of structural features of some mutagenic and teratogenic pesticides,” in Effect of Chronic Exposure to Pesticides on Animal Systems, J. E. Chembers and J. D. Yarbrough, Eds., pp. 177–209, Raven Press, New York, NY, USA, 1982. View at Google Scholar
  8. A. M. El-Sharkawy, S. Z. Abdel-Rahman, A. A. Hassan, M. H. Gabr, S. M. El-Zoghby, and S. M. El-Sewedy, “Biochemical effects of some insecticides on the metabolic enzymes regulating glutathione metabolism,” Bulletin of Environmental Contamination and Toxicology, vol. 52, no. 4, pp. 505–510, 1994. View at Google Scholar · View at Scopus
  9. L. Brenner, “Malathion fact sheet,” Journal of Pesticide Reform, vol. 12, pp. 1–17, 1992. View at Google Scholar
  10. J. Brodeur and K. P. DuBois, “Studies on factors influencing the acute toxicity of malathion and malaoxon in rats,” Canadian Journal of Physiology and Pharmacology, vol. 45, no. 4, pp. 621–631, 1967. View at Google Scholar · View at Scopus
  11. W. N. Aldridge, J. W. Miles, D. L. Mount, and R. D. Verschoyle, “The toxicological properties of impurities in malathion,” Archives of Toxicology, vol. 42, no. 2, pp. 95–106, 1979. View at Google Scholar · View at Scopus
  12. G. Cabello, M. Valenzuela, A. Vilaxa et al., “A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition,” Environmental Health Perspectives, vol. 109, no. 5, pp. 471–479, 2001. View at Google Scholar · View at Scopus
  13. A. Bhatia, M. Makkar, and N. Sohal, “Effect of subchronic and sublethal doses of malathion on some haematological and immunological parameters,” International Journal of Environmental Studies, vol. 51, no. 1, pp. 59–66, 1996. View at Google Scholar · View at Scopus
  14. R. Rezg, B. Mornagui, M. El-Arbi, A. Kamoun, S. El-Fazaa, and N. Gharbi, “Effect of subchronic exposure to malathion on glycogen phosphorylase and hexokinase activities in rat liver using native PAGE,” Toxicology, vol. 223, no. 1-2, pp. 9–14, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. R. Rezg, B. Mornagui, A. Kamoun, S. El-Fazaa, and N. Gharbi, “Effect of subchronic exposure to malathion on metabolic parameters in the rat,” Comptes Rendus Biologies, vol. 330, no. 2, pp. 143–147, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. L. Saadi, N. Lebaili, and M. Benyoussi, “Exploration of cytotoxic effect of malathion on some rat organs structure,” Communications in Agricultural and Applied Biological Sciences, vol. 73, no. 4, pp. 875–881, 2008. View at Google Scholar · View at Scopus
  17. H. Kataoka, “Chromatographic analysis of lipoic acid and related compounds,” Journal of Chromatography B, vol. 717, no. 1-2, pp. 247–262, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Lachman, K. Hamouz, M. Orsak, and V. Pivec, “Potato tubers as a significant source of antioxidants in human nutrition,” Rostlinna Vyroba, vol. 46, no. 5, pp. 231–236, 2000. View at Google Scholar · View at Scopus
  19. L. Packer, H. J. Tritschler, and K. Wessel, “Neuroprotection by the metabolic antioxidant α-lipoic acid,” Free Radical Biology and Medicine, vol. 22, no. 1-2, pp. 359–378, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. T. M. Hagen, R. T. Ingersoll, J. Lykkesfeldt et al., “(R)-α-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate,” FASEB Journal, vol. 13, no. 2, pp. 411–418, 1999. View at Google Scholar · View at Scopus
  21. L. Packer, K. Kraemer, and G. Rimbach, “Molecular aspects of lipoic acid in the prevention of diabetes complications,” Nutrition, vol. 17, no. 10, pp. 888–895, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. O. Yilmaz, Y. Ozkan, M. Yildirim, A. I. Ozturk, and Y. Ersan, “Effects of alpha lipoic acid, ascorbic acid-6-palmitate, and fish oil on the glutathione, malonaldehyde, and fatty acids levels in erythrocytes of streptozotocin induced diabetic male rats,” Journal of Cellular Biochemistry, vol. 86, no. 3, pp. 530–539, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. S. D. Wollin and P. J. H. Jones, “α-lipoic acid and cardiovascular disease,” Journal of Nutrition, vol. 133, no. 11, pp. 3327–3330, 2003. View at Google Scholar · View at Scopus
  24. S. Matsugo, L.-J. Yan, T. Konishi et al., “The lipoic acid analogue 1,2-diselenolane-3-pentanoic acid protects human low density lipoprotein against oxidative modification mediated by copper ion,” Biochemical and Biophysical Research Communications, vol. 240, no. 3, pp. 819–824, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. P. Arivazhagan, T. Thilakavathy, K. Ramanathan, S. Kumaran, and C. Panneerselvam, “Effect of DL-α-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats,” The Journal of Nutritional Biochemistry, vol. 13, no. 10, pp. 619–624, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Singh, L. D. Sharma, A. H. Ahmad, and S. P. Singh, “Fenvalerate induced dermal toxicity in buffalo calves,” Journal of Applied Animal Research, vol. 16, no. 2, pp. 205–210, 1999. View at Google Scholar · View at Scopus
  27. H. Kaur, A. K. Srivastava, S. K. Garg, and D. Prakash, “Subacute oral toxicity of chlorpyriphos in goats with particular reference to blood biochemical and pathomorpholigical alteration,” Indian Journal of Toxicology, vol. 7, no. 2, pp. 83–90, 2000. View at Google Scholar
  28. M. Mohssen, “Biochemical and histopathological changes in serum creatinine and kidney induced by inhalation of Thimet (phorate) in male Swiss albino mouse, Mus musculus,” Environmental Research, vol. 87, no. 1, pp. 31–36, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. S. P. Singh, L. D. Sharma, S. P. Singh, and A. H. Ahmad, “Haematobiochemical profiles in cockerels following prolong feeding of fenvalerate,” Indian Journal of Agronomy, vol. 8, no. 2, pp. 141–145, 2003. View at Google Scholar
  30. U. Jayasree, A. Gopala Reddy, K. S. Reddy, and B. Kalakumar, “Study on the mechanism of toxicity of deltamethrin in poultry,” Indian Journal of Toxicology, vol. 10, no. 2, pp. 111–114, 2003. View at Google Scholar
  31. M. I. Yousef, F. M. El-Demerdash, K. I. Kamel, and K. S. Al-Salhen, “Changes in some hematological and biochemical indices of rabbits induced by isoflavones and cypermethrin,” Toxicology, vol. 189, no. 3, pp. 223–234, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Jabbar, S. A. Khawaja, A. Iqbal, and S. A. Malik, “Effect of malathion and methyl-parathion on rat liver enzymes,” Journal of the Pakistan Medical Association, vol. 40, no. 11, pp. 266–270, 1990. View at Google Scholar · View at Scopus
  33. M. A. Shah and P. K. Gupta, “Subacute toxicity studies on permethrin,” Indian Journal of Toxicology, vol. 8, no. 1, pp. 61–67, 2001. View at Google Scholar
  34. N. Choudhary and S. C. Joshi, “Effect of short term endosulfan on haematology and serum analysis of male rat,” Indian Journal of Toxicology, vol. 9, no. 2, pp. 83–87, 2002. View at Google Scholar
  35. U. K. Garg, A. K. Pal, G. J. Jha, and S. B. Jadhao, “Haemato-biochemical and immuno-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks,” International Immunopharmacology, vol. 4, no. 13, pp. 1709–1722, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. O. Y. Adeniran, M. A. Fafunso, O. Adeyemi, A. O. Lawal, A. Ologundudu, and A. A. Omonkhua, “Biochemical effects of pesticides on serum and urinological system of rats,” Journal of Applied Sciences, vol. 6, no. 3, pp. 668–672, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. O. E. Etim, E. O. Farombi, I. F. Usoh, and E. J. Akpan, “The protective effect of aloe vera juice on lindane induced hepatotoxicity and genotoxicity,” Pakistan Journal of Pharmaceutical Sciences, vol. 19, no. 4, pp. 337–340, 2006. View at Google Scholar · View at Scopus
  38. M. Kerem, N. Bedirli, N. Gurbuz et al., “Effects of acute fenthion toxicity on liver and kidney function and histology in rats,” Turkish Journal of Medical Sciences, vol. 37, no. 5, pp. 281–288, 2007. View at Google Scholar · View at Scopus
  39. A. A. Attia and H. M. Nasr, “Dimethoate-induced changes in biochemical parameters of experimental rat serum and its neutralization by black seed (Nigella sativa L.) oil,” Slovak Journal of Animal Science, vol. 42, no. 2, pp. 87–94, 2009. View at Google Scholar
  40. S. Tos-Luty, D. Obuchowska-Przebirowska, J. Latuszynska, M. Tokarska-Rodak, and A. Haratym-Maj, “Dermal and oral toxicity of malathion in rats,” Annals of Agriculture and Environmental Medicine, vol. 10, no. 1, pp. 101–106, 2003. View at Google Scholar · View at Scopus
  41. A. Yavasoglu, F. Sayim, Y. Uyanikgil, M. Turgut, and N. U. Karabay-Yavasoglu, “The pyrethroid cypermethrin-induced biochemical and histological alterations in rat liver,” Journal of Health Science, vol. 52, no. 6, pp. 774–780, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. H. Abdel Razik, Farrag, and S. E. M. Shalby, “Comparative histopathological and histochemical studies on IGR, lufenuron and profenofos insecticide albino rats,” Journal of Applied Sciences Research, vol. 3, no. 5, pp. 377–386, 2007. View at Google Scholar
  43. S. Afshar, A. A. Farshid, R. Heidari, and M. Ilkhanipour, “Histopathological changes in the liver and kidney tissues of Wistar albino rat exposed to fenitrothion,” Toxicology and Industrial Health, vol. 24, no. 9, pp. 581–586, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. P. Sandhya and P. Varalakshmi, “Effect of lipoic acid administration on gentamicin-induced lipid peroxidation in rats,” Journal of Applied Toxicology, vol. 17, no. 6, pp. 405–408, 1997. View at Google Scholar · View at Scopus
  45. K. P. Malarkodi, A. V. Balachandar, and P. Varalakshmi, “The influence of lipoic acid on adriamycin induced nephrotoxicity in rats,” Molecular and Cellular Biochemistry, vol. 247, no. 1-2, pp. 15–22, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. Z. E. Suntres, “Prophylaxis against lipopolysaccharide-induced liver injuries by lipoic acid in rats,” Pharmacological Research, vol. 48, no. 6, pp. 585–591, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Pari and P. Murugavel, “Protective effect of α-lipoic acid against chloroquine-induced hepatotoxicity in rats,” Journal of Applied Toxicology, vol. 24, no. 1, pp. 21–26, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  48. E. Dulundu, Y. Ozel, U. Topaloglu et al., “Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats,” Pharmacology, vol. 79, no. 3, pp. 163–170, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. A. O. Abdel-Zaher, R. H. Abdel-Hady, M. M. Mahmoud, and M. M. Y. Farrag, “The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage,” Toxicology, vol. 243, no. 3, pp. 261–270, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. O. Sehirli, E. Sener, S. Cetinel, M. Yüksel, N. Gedik, and G. Sener, “α-lipoic acid protects against renal ischaemia-reperfusion injury in rats,” Clinical and Experimental Pharmacology and Physiology, vol. 35, no. 3, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. T. S. Shanmugarajan, D. Sivaraman, I. Somasundaram et al., “Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury,” Toxicology and Industrial Health, vol. 24, no. 10, pp. 635–642, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. K. P. Kang, D. H. Kim, Y. J. Jung et al., “Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation,” Nephrology Dialysis Transplantation, vol. 24, no. 10, pp. 3012–3020, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. R. S. Ahmed, V. Seth, S. T. Pasha, and B. D. Banerjee, “Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats,” Food and Chemical Toxicology, vol. 38, no. 5, pp. 443–450, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Akhgari, M. Abdollahi, A. Kebryaeezadeh, R. Hosseini, and O. Sabzevari, “Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats,” Human & Experimental Toxicology, vol. 22, no. 4, pp. 205–211, 2003. View at Publisher · View at Google Scholar · View at Scopus
  55. J. J. Fortunato, F. R. Agostinho, G. Z. Réus, F. C. Petronilho, F. Dal-Pizzol, and J. Quevedo, “Lipid peroxidative damage on malathion exposure in rats,” Neurotoxicity Research, vol. 9, no. 1, pp. 23–28, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. A. P. da Silva, M. Farina, J. L. Franco, A. L. Dafre, J. Kassa, and K. Kuca, “Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex,” NeuroToxicology, vol. 29, no. 1, pp. 184–189, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  57. J. L. Franco, T. Posser, J. J. Mattos et al., “Zinc reverses malathion-induced impairment in antioxidant defenses,” Toxicology Letters, vol. 187, no. 3, pp. 137–143, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  58. W. Jones, X. Li, Z.-C. Qu, L. Perriott, R. R. Whitesell, and J. M. May, “Uptake, recycling, and antioxidant actions of α-lipoic acid in endothelial cells,” Free Radical Biology and Medicine, vol. 33, no. 1, pp. 83–93, 2002. View at Publisher · View at Google Scholar · View at Scopus
  59. T. W. Nichols Jr., “α-lipoic acid: biological effects and clinical implications,” Alternative Medicine Review, vol. 2, no. 3, pp. 177–183, 1997. View at Google Scholar · View at Scopus
  60. M. T. Islam, “Antioxidant activities of dithiol alpha-lipoic acid,” Bangladesh Journal of Medical Science, vol. 8, no. 3, pp. 46–51, 2009. View at Publisher · View at Google Scholar