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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 218752, 10 pages
Review Article

Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses

Department of Microbiology and Immunology, Queen's University, Kingston, ON, Canada K7L 3N6

Received 11 December 2009; Accepted 9 March 2010

Academic Editor: Kim Klonowski

Copyright © 2010 Julia Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vaccines intended to induce a cytotoxic CD8+ T-cell response are highly sought after. However, some of these vaccines can be problematic if they replicate in the host. An alternative strategy is to exploit cross-presentation of exogenous antigens to express peptides on major histocompatibility complex (MHC) class I molecules. During cross-presentation, the delivered exogenous antigen can be taken up and processed through diverse mechanisms. Here, we will discuss the recent advances regarding the complex nature of the cross-priming process and the models that reflect its relevance in vivo. Moreover, we summarize current data that explore potential adjuvants and vaccine vectors that deliver antigens to activate CD8+ T cells relying on cross-presentation.