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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 231832, 7 pages
Research Article

Glucagon Effects on Ischemic Vasodilatation in the Isolated Rat Heart

1Department of Physiology, Medical Faculty, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
2Research Center of Serbian Academy of Arts and Sciences and the University of Kragujevac, 34000 Kragujevac, Serbia

Received 30 July 2009; Revised 30 October 2009; Accepted 19 January 2010

Academic Editor: Abdel A. Abdel-Rahman

Copyright © 2010 Mirko Rosic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The myocardial reperfusion following ischemia leads to the ischemic vasodilation by affecting the release of various vasoactive substances, such as free radicals, NO, and histamine. In addition, some evidences suggest that glucagon itself may alter the release of those substances. In this study, we investigated the ischemic vasodilation of the isolated rat heart, as well as the concentrations of NO, TBARS, and histamine in the coronary venous effluent either in the presence or in the absence of glucagon. Our results showed that in the presence of glucagon, there was a faster restoration of coronary perfusion pressure during ischemic vasodilation compared to the absence of glucagon ( 1 2 4 ± 5 . 6 versus 8 1 ± 5 . 2  s) with no apparent changes in TBARS concentration. The glucagon's administration leads to the decreased release of histamine by approximately 35%. Biphasic release of NO in the presence of glucagon initially showed augmentation by 60%, followed by the significant attenuation of 45%.