Aquaporin-6 Expression in the Cochlear Sensory Epithelium Is Downregulated by Salicylates
Figure 6
Effect of aspirin treatment on aquaporin-6 protein in the mouse inner ear. Mice were treated with saline (a), (b) and salicylate (c), (d) as described in Methods. Same conditions as Figure 5. In both the organ of Corti (a), (c) and vestibular epithelia (b), (d), AQP6 labeling was lost or strongly attenuated. In vestibular epithelia of saline treated mice, AQP6 was present, possibly in supporting cells. Inset in (b) shows a 2.5 magnification of the region in the box displaying labeling of the apical part of the hair cell (above the nucleus in the inset) and of the thin supporting cells (whose nuclei are deeper in the epithelium and therefore not in the inset). The micrographs are representative of four separate experiments. Scale bar: 20 m ((a), (c)), 10 m ((b), (d)).
