Gene Transfer into the Lung by Nanoparticle Dextran-Spermine/Plasmid DNA Complexes

<table>Luciferase expression (RLU/mg protein) in the trachea and lung of BALB/c mice following administration of naked pCIKLux, dextran-spermine only (D-SPM), and various weight-mixing ratios of D-SPM/pCIKlux complexes ranging 14 to 18 at 2 days posttreatment. The amount of DNA was kept to 10 <svg height="9.6750002" id="M35" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜇</tspan>
</text>
</g>
</g>
</svg>g. Untreated mice was served as the control. Data are presented as mean ± S.E.M from 6 animals.</table>

BioMed Research International

fig5

Figure 5

Figure 5: Gene Transfer into the Lung by Nanoparticle Dextran-Spermine/Plasmid DNA Complexes 