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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 321082, 9 pages
http://dx.doi.org/10.1155/2010/321082
Review Article

Genetic Risk for Recurrent Urinary Tract Infections in Humans: A Systematic Review

1Department of Mother-Child and Biology-Genetics, Section of Pediatrics, University of Verona, Piazzale L. Scuro, 10, 37134 Verona, Italy
2Department of Mother and Child and Biology-Genetics, Section of Biology and Genetics, University of Verona, Verona 37134, Italy
3Division of Neonatology, Catholic University of the Sacred Heart, Rome 00168, Italy
4Department of Pathology and Laboratory Medicine, Immunohematology and Transfusion Center, University Hospital of Parma, Parma 43121, Italy
5Neonatal Intensive Care Unit, University of Cagliari, Cagliari 09124, Italy

Received 31 July 2009; Accepted 25 February 2010

Academic Editor: Wenjiang J. Fu

Copyright © 2010 M. Zaffanello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. C. Craig, “Urinary tract infection: new perspectives on a common disease,” Current Opinion in Infectious Diseases, vol. 14, no. 3, pp. 309–313, 2001. View at Google Scholar · View at Scopus
  2. M. Nuutinen and M. Uhari, “Recurrence and follow-up after urinary tract infection under the age of 1 year,” Pediatric Nephrology, vol. 16, no. 1, pp. 69–72, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Le Saux, B. Pham, and D. Moher, “Evaluating the benefits of antimicrobial prophylaxis to prevent urinary tract infections in children: a systematic review,” Canadian Medical Association Journal, vol. 163, no. 5, pp. 523–529, 2000. View at Google Scholar · View at Scopus
  4. U. Jodal and J. Winberg, “Pyelonephritis. Report of the 4th International Symposium, Goteborg, Sweden 1986,” Pediatric Nephrology, vol. 1, no. 2, pp. 248–252, 1987. View at Google Scholar · View at Scopus
  5. W. J. Hopkins, J. Elkahwaji, C. Kendziorski, A. R. Moser, P. M. Briggs, and K. A. Suhs, “Quantitative trait loci associated with susceptibility to bladder and kidney infections induced by Escherichia coli in female C3H/HeJ mice,” Journal of Infectious Diseases, vol. 199, no. 3, pp. 355–361, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. G. Finer and D. Landau, “Pathogenesis of urinary tract infections with normal female anatomy,” Lancet Infectious Diseases, vol. 4, no. 10, pp. 631–635, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. B. Ragnarsdóttir, H. Fischer, G. Godaly et al., “TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections,” European Journal of Clinical Investigation, vol. 38, supplement 2, pp. 12–20, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. W. J. Hopkins, D. T. Uehling, and D. S. Wargoski, “Evaluation of a familial predisposition to recurrent urinary tract infections in women,” American Journal of Medical Genetics, vol. 83, no. 5, pp. 422–424, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. C. M. Stauffer, B. van der Weg, R. Donadini, G. P. Ramelli, S. Marchand, and M. G. Bianchetti, “Family history and behavioral abnormalities in girls with recurrent urinary tract infections: a controlled study,” Journal of Urology, vol. 171, no. 4, pp. 1663–1665, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. D. Scholes, T. M. Hooton, P. L. Roberts, A. E. Stapleton, K. Gupta, and W. E. Stamm, “Risk factors for recurrent urinary tract infection in young women,” Journal of Infectious Diseases, vol. 182, no. 4, pp. 1177–1182, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. W. J. Hopkins, A. Gendron-Fitzpatrick, D. O. McCarthy, J. E. Haine, and D. T. Uehling, “Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection,” Infection and Immunity, vol. 64, no. 4, pp. 1369–1372, 1996. View at Google Scholar · View at Scopus
  12. L. Hagberg, R. Hull, S. Hull et al., “Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice,” Infection and Immunity, vol. 46, no. 3, pp. 839–844, 1984. View at Google Scholar
  13. B. Frendéus, G. Godaly, L. Hang, D. Karpman, and C. Svanborg, “Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis,” Journal of Infectious Diseases, vol. 183, pp. S56–S60, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. L. Hagberg, D. E. Briles, and C. S. Edén, “Evidence for separate genetic defects in C3H/HeJ and C3HeB/FeJ mice, that affect susceptibility to gram-negative infections,” Journal of Immunology, vol. 134, no. 6, pp. 4118–4122, 1985. View at Google Scholar · View at Scopus
  15. C. S. Edén, R. Kulhavy, S. Mårild, S. J. Prince, and J. Mestecky, “Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis,” Scandinavian Journal of Immunology, vol. 21, no. 4, pp. 305–313, 1985. View at Google Scholar · View at Scopus
  16. B. Frendéus, G. Godaly, L. Hang, D. Karpman, A.-C. Lundstedt, and C. Svanborg, “Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart,” Journal of Experimental Medicine, vol. 192, no. 6, pp. 881–890, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Karoly, A. Fekete, N. F. Banki et al., “Heat shock protein 72 (HSPA1B) gene polymorphism and toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children,” Pediatric Research, vol. 61, no. 3, pp. 371–374, 2007. View at Publisher · View at Google Scholar · View at PubMed
  18. A.-C. Lundstedt, S. McCarthy, M. C. U. Gustafsson et al., “A genetic basis of susceptibility to acute pyelonephritis,” PLoS One, vol. 2, no. 9, article e825, 2007. View at Publisher · View at Google Scholar · View at PubMed
  19. A.-C. Lundstedt, I. Leijonhufvud, B. Ragnarsdottir, D. Karpman, B. Andersson, and C. Svanborg, “Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection,” Journal of Infectious Diseases, vol. 195, no. 8, pp. 1227–1234, 2007. View at Publisher · View at Google Scholar · View at PubMed
  20. A. Smithson, M. R. Sarrias, J. Barcelo et al., “Expression of interleukin-8 receptors (CXCR1 and CXCR2) in premenopausal women with recurrent urinary tract infections,” Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 12, pp. 1358–1363, 2005. View at Publisher · View at Google Scholar · View at PubMed
  21. T. R. Hawn, D. Scholes, S. S. Li et al., “Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women,” PLoS ONE, vol. 4, no. 6, article e5990, 2009. View at Publisher · View at Google Scholar · View at PubMed
  22. Y. Tabel, A. Berdeli, and S. Mir, “Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children,” International Journal of Immunogenetics, vol. 34, no. 6, pp. 399–405, 2007. View at Publisher · View at Google Scholar · View at PubMed
  23. B. Ragnarsdóttir, M. Samuelsson, M. C. U. Gustafsson, I. Leijonhufvud, D. Karpman, and C. Svanborg, “Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria,” Journal of Infectious Diseases, vol. 196, no. 3, pp. 475–484, 2007. View at Publisher · View at Google Scholar · View at PubMed
  24. H. E. Yim, I. S. Bae, K. H. Yoo, Y. S. Hong, and J. W. Lee, “Genetic control of VEGF and TGF-β1 gene polymorphisms in childhood urinary tract infection and vesicoureteral reflux,” Pediatric Research, vol. 62, no. 2, pp. 183–187, 2007. View at Publisher · View at Google Scholar · View at PubMed
  25. J. C. T. Lu, S. G. Coca, U. D. Patel, L. Cantley, and C. R. Parikh, “Searching for genes that matter in acute kidney injury: a systematic review,” Clinical Journal of the American Society of Nephrology, vol. 4, no. 6, pp. 1020–1031, 2009. View at Publisher · View at Google Scholar · View at PubMed
  26. S. J. Chanock, T. Manolio, M. Boehnke et al., “Replicating genotype-phenotype associations,” Nature, vol. 447, no. 7145, pp. 655–660, 2007. View at Publisher · View at Google Scholar · View at PubMed
  27. L. Artifoni, S. Negrisolo, G. Montini et al., “Interleukin-8 and CXCR1 receptor functional polymorphisms and susceptibility to acute pyelonephritis,” Journal of Urology, vol. 177, no. 3, pp. 1102–1106, 2007. View at Publisher · View at Google Scholar · View at PubMed
  28. M. Bajpai, A. Pratap, C. Somitesh, and J. Tyagi, “Angiotensin converting enzyme gene polymorphism in Asian Indian children with congenital uropathies,” Journal of Urology, vol. 171, no. 2 I, pp. 838–840, 2004. View at Publisher · View at Google Scholar · View at PubMed
  29. S. J. Cho and S. J. Lee, “ACE gene polymorphism and renal scar in children with acute pyelonephritis,” Pediatric Nephrology, vol. 17, no. 7, pp. 491–495, 2002. View at Publisher · View at Google Scholar · View at PubMed
  30. S. A. Cotton, R. A. Gbadegesin, S. Williams et al., “Role of TGF-β1 in renal parenchymal scarring following childhood urinary tract infection,” Kidney International, vol. 61, no. 1, pp. 61–67, 2002. View at Publisher · View at Google Scholar · View at PubMed
  31. H. Erdogan, S. Mir, E. Serdaroglu, A. Berdeli, and N. Aksu, “Is ACE gene polymorphism a risk factor for renal scarring with low-grade reflux?” Pediatric Nephrology, vol. 19, no. 7, pp. 734–737, 2004. View at Publisher · View at Google Scholar · View at PubMed
  32. A. Ece, S. Tekes, F. Gürkan, M. Bilici, and T. Budak, “Polymorphisms of the angiotensin converting enzyme and angiotensin II type 1 receptor genes and renal scarring in non-uropathic children with recurrent urinary tract infection,” Nephrology, vol. 10, no. 4, pp. 377–381, 2005. View at Publisher · View at Google Scholar · View at PubMed
  33. R. A. Gbadegesin, S. A. Cotton, C. J. Watson, P. E. C. Brenchley, and N. J. A. Webb, “Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection,” International Journal of Immunogenetics, vol. 33, no. 1, pp. 49–53, 2006. View at Publisher · View at Google Scholar · View at PubMed
  34. K. Hohenfellner, T. E. Hunley, R. Brezinska et al., “ACE I/D gene polymorphism predicts renal damage in congenital uropathies,” Pediatric Nephrology, vol. 13, no. 6, pp. 514–518, 1999. View at Publisher · View at Google Scholar
  35. P. Kimball and F. Reid, “Tumor necrosis factor β gene polymorphisms associated with urinary tract infections after renal transplantation,” Transplantation, vol. 73, no. 7, pp. 1110–1112, 2002. View at Google Scholar
  36. R. Pardo, S. Málaga, E. Coto et al., “Renin-angiotensin system polymorphisms and renal scarring,” Pediatric Nephrology, vol. 18, no. 2, pp. 110–114, 2003. View at Publisher · View at Google Scholar · View at PubMed
  37. A. Yoneda, S. Cascio, T. Oue, B. Chertin, and P. Puri, “Risk factors for the development of renal parenchymal damage in familial vesicoureteral reflux,” Journal of Urology, vol. 168, no. 4 II, pp. 1704–1707, 2002. View at Google Scholar
  38. R. H. Mak and H.-J. Kuo, “Pathogenesis of urinary tract infection: an update,” Current Opinion in Pediatrics, vol. 18, no. 2, pp. 148–152, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. N. J. A. Webb and P. E. C. Brenchley, “Cytokines and cell adhesion molecules in the inflammatory response during acute pyelonephritis,” Nephron Experimental Nephrology, vol. 96, no. 1, pp. e1–e6, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. G. Godaly, G. Bergsten, L. Hang et al., “Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection,” Journal of Leukocyte Biology, vol. 69, no. 6, pp. 899–906, 2001. View at Google Scholar · View at Scopus
  41. H. Fischer, M. Yamamoto, S. Akira, B. Beutler, and C. Svanborg, “Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection,” European Journal of Immunology, vol. 36, no. 2, pp. 267–277, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. V. Hancock, A. S. Seshasayee, D. W. Ussery, N. M. Luscombe, and P. Klemm, “Transcriptomics and adaptive genomics of the asymptomatic bacteriuria Escherichia coli strain 83972,” Molecular Genetics and Genomics, vol. 279, no. 5, pp. 523–534, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. G. Williams and J. C. Craig, “Prevention of recurrent urinary tract infection in children,” Current Opinion in Infectious Diseases, vol. 22, no. 1, pp. 72–76, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. J. E. Scherberich and A. Hartinger, “Impact of Toll-like receptor signalling on urinary tract infection,” International Journal of Antimicrobial Agents, vol. 31, pp. S9–S14, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus