Genetic Risk for Recurrent Urinary Tract Infections in Humans: A Systematic Review

Table 1

Summary of the characteristics of the included studies investigating the polymorphisms and/or mRNA or protein expression assessment in patients with recurrent urinary tract infections (CXCR: IL-8 receptor; HSPA1B: Heat shock protein 72; TGF: Transforming growth factor; TIRAP: TIR domain-containing adapter protein; TLR: Toll-like receptor; UTI: urinary tract infection; UTM: urinary tract malformation; VEGF: Vascular endothelial growth factor; VUR: vesicoureteral reflux).

Genes	Polymorphisms	Gene expression	Patient categories	Ethnicity (country)	Urological malformations included	References
HSPA1B	1267A>G	−	Children	Hungarian	VUR	[17]
CXCR1	—	+	Children	(Sweden)	VUR	[13, 16]
	217C>G	+		Caucasians		[18]
	2608G>C	+	Children and adults
	—	+		(Sweden)		[19]
	—	+	Pre-menopausal women	(Spain)	—	[20]
CXCR2	—	+	Pre-menopausal women	(Spain)	—	[20]
	—	+	Children	(Sweden)	VUR	[13, 16]
TLR1	1805G>T	−	Adult women	Caucasian	UTM	[21]
TLR2	2258G>A	−	Children	Turkish	—	[22]
		−	Adult women	Caucasian	UTM	[21]
TLR4	896A>G	−	Adult women	Caucasian	UTM	[21]
	1196C>T	−
	896A>G	−	Children	Hungarian	VUR	[17]
	—	+	Mainly children	(Sweden)		[23]
TRIF	9A>G	+	Mainly children	(Sweden)	VUR	[23]
TRAM	—	+	Mainly children	(Sweden)	VUR	[23]
MyD88	—	+	Mainly children	(Sweden)	VUR	[23]
SIGIRR	—	+	Mainly children	(Sweden)	VUR	[23]
TLR5	1174C>T	−	Adult women	Caucasian	UTM	[21]
TIRAP	589C>T	−	Adult women	Caucasian	UTM	[21]
	558C>T	−
VEGF	460T>C	−	Children	Korean	VUR	[24]
	405G>C	−
TGF- β1	509C>T	−
	800G>A	−	Children	Korean	VUR	[24]
	869T>C	−