TY - JOUR
A2 - William, Schwan
AU - Sun, Juan
AU - Hu, Yanxin
AU - Cao, Shanping
AU - Zhang, Guozhong
AU - Sun, Lun-Quan
AU - Wang, Ming
PY - 2010
DA - 2010/07/20
TI - Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent
SP - 362524
VL - 2010
AB - Nu-3 [butyl-phosphate-5′-thymidine-3′-phosphate-butyl] is a modified nucleotide that has been shown to have antimicrobial activity against a range of bacteria including Pseudomonas aeruginosa. However, data on the toxicological profile of Nu-3 are still lacking. In the present study, the toxicity of Nu-3 was evaluated by the following studies: acute oral toxicity, dermal and mucous membrane irritation, multiple-dose toxicity and genotoxicity in vivo and vitro. The acute oral toxicity test in mice showed that Nu-3 had an LD50 of 2001mg/kg body weight. The irritation tests on rats revealed that Nu-3 was not irritant, with an irritation scoring of 0. The multiple-dose toxicity study in rats showed that Nu-3 did not cause significant changes in histology, selected serum chemistry, and hematological parameters compared to the controls. Rats administrated with multiple-doses of Nu-3 showed no visible toxic symptoms. Both in vitro and in vivo, Nu-3 exhibited no notable genetic toxicity. Overall, the data suggest that Nu-3 is hypotoxic or nontoxic antimicrobial compound that warrants being further developed for treating Pseudomonas aeruginosa infection.
SN - 2314-6133
UR - https://doi.org/10.1155/2010/362524
DO - 10.1155/2010/362524
JF - Journal of Biomedicine and Biotechnology
PB - Hindawi Publishing Corporation
KW -
ER -