Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent

Table 5

The numbers of micronucleated PCE of in vivo mouse micronucleus Assay.

Groups	Dose	No. of Rats	No. of PEC/Rat	♂ (5)		♀ (5)
				No. of micronucleated PCE	Rate* of micronucleated PCE (%)	No. of micronucleated PCE	Rate of micronucleated PCE (%)
1	1000 mg/kg Nu-3	10	2000	18 ± 2.5	0.9	20 ± 0.5	1.0
2	500 mg/kg Nu-3	10	2000	8 ± 0.5	0.4	8 ± 0.5	0.4
3	25 mg/kg Nu-3	10	2000	7 ± 1.5	0.35	8 ± 0.5	0.4
4	Saline	10	2000	6 ± 1.5	0.3	7 ± 0.5	0.35
5	Cyclophosphamide	10	2000	58 ± 2.5	2.9	60 ± 0.5	3.0

*The rate was calculated with the number of polychromatic erythrocytes (PCEs) that contained at least one micronucleus divided by 2000.