BioMed Research International

Research Article

Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia

Table 3

Parental genotype distributions under mating symmetry and mating asymmetry.
Mating typeParental genotypesExpected distribution
(Mother-Father)Mating symmetryMating asymmetry
011-11 𝑁 ∗ 𝜇 0 𝑁 ∗ 𝜇 0
111-12 𝑁 ∗ 𝜇 1 ( 2 − 𝐶 1 ) ∗ 𝑁 ∗ 𝜇 1
12-11 𝑁 ∗ 𝜇 1 𝐶 1 ∗ 𝑁 ∗ 𝜇 1
211-22 𝑁 ∗ 𝜇 2 ( 2 − 𝐶 2 ) ∗ 𝑁 ∗ 𝜇 2
22-11 𝑁 ∗ 𝜇 2 𝐶 2 ∗ 𝑁 ∗ 𝜇 2
312-12 𝑁 ∗ 𝜇 3 𝑁 ∗ 𝜇 3
412-22 𝑁 ∗ 𝜇 4 ( 2 − 𝐶 4 ) ∗ 𝑁 ∗ 𝜇 4
22-12 𝑁 ∗ 𝜇 4 𝐶 4 ∗ 𝑁 ∗ 𝜇 4
522-22 𝑁 ∗ 𝜇 5 𝑁 ∗ 𝜇 5
Alleles for a biallelic locus are denoted 1 and 2 and the corresponding genotypes 11, 12 or 22. 𝑁 indicates the number of individuals in the sample; 𝜇 𝑖 the 𝑖 th mating type probability under the assumption of random mating; 𝐶 𝑖 the mating-pair disequilibrium for the 𝑖 th parental couple. 𝐶 is a multiplicative factor between 0 and 2 that describes the over representation ( > 1), under representation ( < 1) or symmetry (=1) of a mate-pair combination in the corresponding 𝑖 th mating type.