Computational Method for Estimating DNA Copy Numbers in Normal Samples, Cancer Cell Lines, and Solid Tumors Using Array Comparative Genomic Hybridization
Figure 4
Results of CN analysis of colon tumor sample (collected from male subject) significantly contaminated with benign tissue (48%). (a) Signal intensity of SNPs ( axis) for this sample after adjustment on genome size but before adjustment on contamination with benign tissue. (b) Correct CN solution for this sample after adjustment on both genome size and contamination with benign tissue. (c) Incorrect CN solution for this sample after adjustment on genome size but without adjustment on contamination with benign tissue.
