Research Article

MHC I Stabilizing Potential of Computer-Designed Octapeptides

Figure 3

Self-organizing map (SOM) projection of MHC I stabilizing peptides. The SOM was trained with 100,603 octapeptides (603 peptides with known 2 K b binding affinity and 100,000 octamer sequences randomly designed according to the amino acid frequency of M. musculus proteins). Neurons are colored according to the MHC I stabilizing ability of the octapeptides (red: nonstabilizing; blue: mixed; green: stabilizing). (a) Projection of the known 251 stabilizing octapeptides and 24 nonstabilizing octapeptides with amino acid sequences corresponding to the canonical motif in all three positions. (b) Projection of the known 251 stabilizing octapeptides and 93 nonstabilizing octapeptides with amino acid sequences corresponding to the canonical motif in two positions. (c) Projection of the known 251 stabilizing octapeptides and 59 nonstabilizing octapeptides with amino acid sequences corresponding to the canonical motif in only one position.
396847.fig.003a
(a)
396847.fig.003b
(b)
396847.fig.003c
(c)